Monitoring the Facial Flush: A Methodological Study

  • S. A. Bowcock
  • S. Medbak
  • E. D. Cooke


Facial flushing following the oral administration of a hypoglycemic agent (chlorpropamide) and alcohol may be genetically determined and is associated with an elevation of met-encephalin levels in plasma.1,2,3,4


Flushing Chlorpropamide 


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  1. 1.
    R. D. Leslie, D. A. Pyke, Chlorpropamide-alcohol flushing:a dominantly inherited trait associated with diabetes, Br. Med. J. 2: 1519 (1978).CrossRefGoogle Scholar
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    A. H. Barnet, D. A. Pyke, Chlorpropamide-alcohol flushing and large-vessel disease in non-insulin dependent diabetics, Br. Med. J. 2: 261 (1980).CrossRefGoogle Scholar
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    N. E. De Silva, W. M. G. Tunbridge, K. G. M. Alberti, Low incidence of chlorpropamide-alcohol flushing in diet-treated non-insulin dependent diabetics, Lancet 1: 128 (1981).Google Scholar
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    S. Medbak, J. A. H. Wass, V. Clement-Jones, E. D. Cooke, S. A. Bowcock, A. Cudworth, L. M. Rees, Chlorpropamide-alcohol flush and circulating met-encephalin; a positive link, Br. Med. J. 283: 937 (1981).CrossRefGoogle Scholar
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    E. C. Poulton, Qualitative subject assessments are almost always biased: sometimes completely misleading, Br. J. Psychol. 60: 408 (1977).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. A. Bowcock
    • 1
  • S. Medbak
    • 2
  • E. D. Cooke
    • 1
  1. 1.Departments of Medical ElectronicsSt Bartholomew’s HospitalLondonUK
  2. 2.Chemical EndrocrinologySt Bartholomew’s HospitalLondonUK

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