Effects of Sulfhydryl Reagents on Basal and Vasopressin-Stimulated Na+ Transport in the Toad Bladder
The two-barrier, in series, model of Koefoed-Johnsen and Ussing (1958) has been widely accepted as representative of the basic mechanism of transepithelial active Na+ transport. The first step in the process is presumed to be passive penetration of Na+ across the apical plasma membrane driven by the electrochemical gradient, and the second step is active extrusion of Na+ across the basal-lateral plasma membrane. The Na+ pump in the basal-lateral membrane apparently derives its energy from the hydrolysis of ATP (Skou, 1965).
KeywordsApical Membrane Apical Plasma Membrane Serosal Side Sulfhydryl Reagent Toad Bladder
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