Abstract
The two-barrier, in series, model of Koefoed-Johnsen and Ussing (1958) has been widely accepted as representative of the basic mechanism of transepithelial active Na+ transport. The first step in the process is presumed to be passive penetration of Na+ across the apical plasma membrane driven by the electrochemical gradient, and the second step is active extrusion of Na+ across the basal-lateral plasma membrane. The Na+ pump in the basal-lateral membrane apparently derives its energy from the hydrolysis of ATP (Skou, 1965).
This paper is dedicated to Aharon Katzir-Katchalsky; we cherish the memory of his warm friendship and honor him for his distinguished contributions to our field.
Financial support was provided by U. S. PHS National Institute of Arthritis, Metabolism and Digestive Diseases Grant No. AM-13659.
During the tenture of a National Kidney Foundation Fellowship.
During the tenure of a postdoctoral traineeship provided by U. S. PHS National Heart and Lung Institute Grant No. HL-05725.
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© 1975 Plenum Press, New York
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Frenkel, A., Ekblad, E.B.M., Edelman, I.S. (1975). Effects of Sulfhydryl Reagents on Basal and Vasopressin-Stimulated Na+ Transport in the Toad Bladder. In: Eisenberg, H., Katchalski-Katzir, E., Manson, L.A. (eds) Aharon Katzir Memorial Volume. Biomembranes, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7668-2_4
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