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Hormone Receptors, Cyclic Nucleotides, and Control of Cell Function

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The Year in Metabolism 1975–1976

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Abstract

It is now widely recognized that many polypeptide or amine hormones and neurotransmitters act through the intermediation of cyclic 3’,5’-adenosine monophosphate (cAMP). These agonists bind to specific receptors at the outer surface or plasma membrane of the cell and, through a mechanism still under study, activate the enzyme adenylate cyclase, which catalyzes the formation of cAMP from ATP. The cAMP generated as a consequence becomes the “second messenger” that interacts with cyclic nucleotide receptors regulating intracellular enzymes that ultimately account for the physiological response. The concentration of cyclic nucleotides in cells can be regulated not only through biosynthesis, but also by enzymatic destruction (cyclic nucleotide phosphodiesterases) or elaboration into the extracellular space.

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  1. Metabolic Diseases Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014, USA

    G. D. Aurbach

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  1. Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois, USA

    Norbert Freinkel M. D. (Kettering Professor of Medicine, Professor of Biochemistry, Director) (Kettering Professor of Medicine, Professor of Biochemistry, Director)

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Aurbach, G.D. (1976). Hormone Receptors, Cyclic Nucleotides, and Control of Cell Function. In: Freinkel, N. (eds) The Year in Metabolism 1975–1976. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7656-9_1

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