Influence of Four Commercial Sensitivity Media on in Vitro Activity of Several Antibiotics

  • G. Th. J. Fabius
  • R. P. Mouton
Part of the Chemotherapy book series (CT, volume 2)


MIC’s and inhibition zones of six antibiotics were determined simultaneously on four commercially available sensitivity test media, by means of standardized procedures. Multiple strains of several bacterial genera were used. Two media proved to be unsuitable for tetracycline and aminoglycoside testing respectively; on one of them, most E. coli strains would be interpreted as being resistant to tetracycline; on the other, most gramnegative rods were marginally sensitive or resistant to the aminoglycosides.These data and other details on differences between the media investigated are discussed in the light of the requirements with regard to performance.


Inhibition Zone Proteus Mirabilis Vitro Activity Inhibition Zone Diameter Normal Human Plasma 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • G. Th. J. Fabius
    • 1
  • R. P. Mouton
    • 1
  1. 1.Division of Clinical Bacteriology, Department of MedicineUniversity HospitalUtrechtThe Netherlands

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