Action Mechanism of 3,4-Dideoxykanamycin B (DKB) on Some Gram-Negative Bacteria
A new antibiotic, 3′,4′-dideoxykanamycin B, abbreviated as DKB, has a broad spectrum of antibacterial activity with a strong selective inhibition on Pseudomonas aeruginosa and kanamycin-resistant Escherichia coli. To study the action modes of DKB, this research was done on the basis of the ultramicroscopic structures and the polypeptide synthesis of the two following bacilli, which had been exposed to DKB.
KeywordsPseudomonas Aeruginosa Klebsiella Pneumoniae Osmium Tetroxide Dense Granule Pulse Label
Unable to display preview. Download preview PDF.
- 1).Konno, K., Oizumi, K., Kumano, N. and Oka, S. (1973), Amer. Rev. Resp. Dis., 108, 101.Google Scholar
- 2).Luzzato, L., Apiron, D. and Schlessinger, D. (1968), Proc. Nat. Acad. Sci., U.S.A., 60, 873.Google Scholar
- 3).Modolell, J. and Davis, B.D. (1968), Proc. Nat. Acad. Sci., U.S.A., 61, 1279.Google Scholar