Butirosin — Pharmacodynamics and Clinical Experience

  • William E. Kunsman
  • William J. Holloway
Part of the Chemotherapy book series (CT, volume 2)


Butirosin is a new neomycin-like aminoglycoside antibiotic exhibiting marked activity against many gram-positive and gram-negative bacteria in vitro and in vivo.1,2,3 The gram-negative spectrum includes the Klebsiella-Enterobacter-Serratia groups as well as Proteus sp. and Pseudomonas sp. Butirosin appears to have less antibacterial potency than gentamicin on a weight basis, but it appears to be less nephrotoxic and considerably less ototoxic in laboratory animals than the older drug.4 These early reports suggested that this decreased toxicity might compensate for the lower potency resulting in a safe, effective compound for use in man.


Hourly Urine Drug Assay Lower Urinary Tract Infection Urinary Tract Infec Sterile Urine 
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  1. 1.
    Dion, H.W., Woo, P.W.K., Willmer, N.E., Kern, D.L., Onaga, J., and Fusari, S.A., “Butirosin, a new aminoglycosidic antibiotic complex: isolation and characterization”, Antimicrobial Agents and Chemotherapy, 2: 84–88, 1972.PubMedCrossRefGoogle Scholar
  2. 2.
    Howells, J.D., Anderson, L.E., Coffey, G.L., Senos, G. D., Underhill, M.A., Vagler, D.L., and Ehrlich, J., “Butirosin, a new aminoglycosidic antibiotic complex: bacterial origin and microbiological studies”, Antimicrobial Agents and Chemotherapy, 2: 78–83, 1972.CrossRefGoogle Scholar
  3. 3.
    Heifetz, C.L., Fisher, M.W., Chodubski, J.A. and DeCarlo, M.O., “Butirosin, a new aminoglycosidic antibiotic complex: antibacterial activity in vitro and in mice”, Antimicrobial Agents and Chemotherapy, 2: 89–94, 1972.PubMedCrossRefGoogle Scholar
  4. 4.
    Heifetz, C.L., Chodubski, J.A., Pearson, I.A., Silverman, C.A., and Fisher, M.W., “Butirosin compared with gentamicin in vitro and in vivo”, Antimicrobial Agents and Chemotherapy, 6: 124–135, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • William E. Kunsman
    • 1
  • William J. Holloway
    • 2
  1. 1.Department of MedicineWilmington Medical CenterWilmingtonUSA
  2. 2.Section of Infectious DiseaseWilmington Medical CenterWilmingtonUSA

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