Butirosin — Pharmacodynamics and Clinical Experience
Butirosin is a new neomycin-like aminoglycoside antibiotic exhibiting marked activity against many gram-positive and gram-negative bacteria in vitro and in vivo.1,2,3 The gram-negative spectrum includes the Klebsiella-Enterobacter-Serratia groups as well as Proteus sp. and Pseudomonas sp. Butirosin appears to have less antibacterial potency than gentamicin on a weight basis, but it appears to be less nephrotoxic and considerably less ototoxic in laboratory animals than the older drug.4 These early reports suggested that this decreased toxicity might compensate for the lower potency resulting in a safe, effective compound for use in man.
KeywordsHourly Urine Drug Assay Lower Urinary Tract Infection Urinary Tract Infec Sterile Urine
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