Evaluation of Tobramycin in Severe Urinary Tract Infection
Tobramycin sulfate is a bactericidal aminoglycoside antibiotic which in animal studies has been shown to have lower acute toxicity and lower nephrotoxicity than gentamicin (1,2). Tobramycin has been shown to have more activity in vitro against Pseudomonas sp. than other aminoglycoside antibiotics (3,4). Tobramycin is excreted unchanged in the urine and assayable blood levels are present for at least eight hours. Studies in patients with renal failure showed that the serum half-life was directly related to the degree of renal impairment and that reduced doses were necessary. This antibiotic was found to be effective against infections due to susceptible organisms in the genitourinary system- Pseudomonas sp., Esch. coli, the Klebsiella-Enterobacter-Serratia group, indole-positive and indole-negative Proteus sp., staphylococci and group D streptococci. Early clinical studies showed that Tobramycin was successful in eradicating infections with Pseudomonas sp. which had prior unsuccessful therapy with gentamicin and/or carbenicillin.
KeywordsAminoglycoside Antibiotic Urinary Tract Obstruction Susceptible Organism Lower Acute Toxicity Satisfactory Clinical Response
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