Evaluation of Tobramycin in Severe Urinary Tract Infection

  • Alan H. Bennett
Part of the Chemotherapy book series (CT, volume 2)


Tobramycin sulfate is a bactericidal aminoglycoside antibiotic which in animal studies has been shown to have lower acute toxicity and lower nephrotoxicity than gentamicin (1,2). Tobramycin has been shown to have more activity in vitro against Pseudomonas sp. than other aminoglycoside antibiotics (3,4). Tobramycin is excreted unchanged in the urine and assayable blood levels are present for at least eight hours. Studies in patients with renal failure showed that the serum half-life was directly related to the degree of renal impairment and that reduced doses were necessary. This antibiotic was found to be effective against infections due to susceptible organisms in the genitourinary system- Pseudomonas sp., Esch. coli, the Klebsiella-Enterobacter-Serratia group, indole-positive and indole-negative Proteus sp., staphylococci and group D streptococci. Early clinical studies showed that Tobramycin was successful in eradicating infections with Pseudomonas sp. which had prior unsuccessful therapy with gentamicin and/or carbenicillin.


Aminoglycoside Antibiotic Urinary Tract Obstruction Susceptible Organism Lower Acute Toxicity Satisfactory Clinical Response 
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  1. 1.
    Meyers, B.R. and Hirschman, S.Z., Pharmacológic Studies on Tobramycin and Comparison with Gentamicin. J. Clin. Pharmacol., 12: 321, 1972.Google Scholar
  2. 2.
    DeRosa, F., Buoncristiani, U., etal., Tobramycin: Toxicological and Pharmacological Studies in Animals and Pharmacokinetic Research in Patients with Varying Degrees of Renal Impairment. J.Int. Med. Res., 2: 100, 1974.Google Scholar
  3. 3.
    Henderson, A. and Byatt, M.E., Sensitivity of Pseudomonas to Tobramycin. Clin. Med., 81: 27, 1974.Google Scholar
  4. 4.
    Klastersky, J., Daneau, D. and deMaertelaer, V., Comparative Study of Tobramycin and Gentamicin with. Special Reference to Anti-Pseudomonas Activity, Clin. Pharacol. Ther., 14: 104, 1973.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Alan H. Bennett
    • 1
  1. 1.Harvard Medical SchoolBostonUSA

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