Pharmacokinetics and Ototoxicity of Gentamicin, Tobramycin and Amikacin

  • P. Federspil
  • E. Tiesler
Part of the Chemotherapy book series (CT, volume 2)

Abstract

The aim of this paper is to give a survey of the pharmacokinetical studies on the ototoxicity of the new aminoglycoside antibiotics Gentamicin, Tobramycin and Amikacin. The animal used was the guinea pig and the antibiotic concentrations were determined by the microbiological method (Bac subtilis ATCC 6633).

Keywords

Toxicity Gentamicin Aminoglycoside Uremia Amikacin 

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • P. Federspil
    • 1
  • E. Tiesler
    • 1
  1. 1.University of the SAARHomburg (SAAR)West Germany

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