The Urinary Excretion of Tobramycin and Gentamicin
Previous studies of the urinary excretion of the aminoglycoside antibiotics, gentamicin and tobramycin, have employed microbiological assay methods and the results obtained have been very variable. The values obtained for the 24 hour urinary excretion of gentamicin in adults with normal renal function have ranged from 0 to 100% of the administered dose and there has been a similar wide range of values for tobramycin excretion (Black and Griffith, 1971, 1974; Regamey et al, 1973; Geddes et al, 1974). This variability in the results obtained is due chiefly to changes in antibiotic activity with different levels of urinary pH (Lamb et al, 1972) and variation in the electrolyte constituents of urine.
KeywordsUrinary Excretion Normal Renal Function Antibiotic Activity Aminoglycoside Antibiotic Microbiological Assay
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