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In Vivo Activity of Sisomicin in Mice

  • M. Scheer
Part of the Chemotherapy book series (CT, volume 2)

Abstract

The in vivo antibacterial activity of sisomicin was demonstrated by its ability to protect mice from death following an intraperitoneal infection by a lethal dose of pathogenic bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus spp., E. coli, Serratia marcescens, Staphylococcus aureus. The therapeutic activity was compared to that of gentamicin. The results indicate, that sisomicin is on average 2 – 3 times more effective in vivo than gentamicin.

Keywords

Staphylococcus Aureus Pseudomonas Aeruginosa Klebsiella Pneumoniae Serratia Marcescens Proteus Mirabilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Waltz, J.A., Moss, E.Z., Oden, E.M. and Weinstein, M.J. (1970)Google Scholar
  2. J. Antibiotics 23, 559Google Scholar
  3. Weinstein, M.J., Marquez, J.A., Testa, R.T., Wagman, G.H., Oden, E.M. and Waltz, J.A. (1970)Google Scholar
  4. J. Antibiotics 23, 551Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • M. Scheer
    • 1
  1. 1.Institute for Medical MicrobiologyBAYER AGD-56 Wuppertal-1West Germany

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