In Vivo Activity of Sisomicin in Mice
The in vivo antibacterial activity of sisomicin was demonstrated by its ability to protect mice from death following an intraperitoneal infection by a lethal dose of pathogenic bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus spp., E. coli, Serratia marcescens, Staphylococcus aureus. The therapeutic activity was compared to that of gentamicin. The results indicate, that sisomicin is on average 2 – 3 times more effective in vivo than gentamicin.
KeywordsStaphylococcus Aureus Pseudomonas Aeruginosa Klebsiella Pneumoniae Serratia Marcescens Proteus Mirabilis
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