Clinical Trial of Sisomycin: Evaluation of Two Different Dosages
Sisomicin is a new aminoglycoside antibiotic structurally related to gentamicin. From data in the literature it is known that the antimicrobial activity of sisomicin is similar to that of gentamicin. However, sisomicin has been reported to have advantageous characteristics, e.g. higher activity against certain bacterial species, effectivity against strains resistant to gentamicin and also a higher bactericidal effect in the presence of serum. These data qualified the drug for a clinical trial. The main purpose of the study was to investigate the pharmacokinetics at two different dose regimens in patients with normal and impaired renal function.
KeywordsCreatinine Clearance Normal Renal Function Impaired Renal Function Aminoglycoside Antibiotic Pyelonephritis Acuta
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