Parenteral Sisomicin for Surgical Infections
Sisomicin, a newly developed aminoglycoside with properties similar to those of gentamicin and tobramycin, recently became available for clinical investigation (3). Initial studies demonstrated it to be highly effective in the treatment of urinary, pulmonary, and selective bacteremic infections due to gram-negative bacilli; yet in few patients with peritonitis, burn infection, or other types of wound sepsis has the antibiotic been evaluated (3). Accordingly, a clinical study of sisomicin in the management of gram-negative surgical infections was undertaken.
KeywordsAminoglycoside Antibiotic Staph Aureus Surgical Infection Wound Sepsis Tube Dilution
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- 1.Bauer, A.W., Kirby, W.M.M., Sherris, J.D., and Tuck, M.: Antibiotic Susceptibility Testing by a Standardized Single Disc Method. Amer. J. Clin. Path. 45: 493, 1966.Google Scholar
- 2.Gavin, T.L., and Town, M.A.: A Microdilution Method for Antibiotic Susceptibility Testing: An Evaluation. Amer. J. Clin. Path., 53: 880, 1970.Google Scholar
- 3.Schering Corporation: Investigators Manual, Bloomfield, 1974.Google Scholar
- 4.Stone, H.H., Kolb, L.D., Geheber, C.E., and Currie, C.A.: Treatment of Surgical Infections with Tobramycin. Amer. Surg., 41: 301, 1974.Google Scholar