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Parenteral Sisomicin for Surgical Infections

  • H. H. Stone
  • L. D. Kolb
  • C. E. Geheber
Part of the Chemotherapy book series (CT, volume 2)

Abstract

Sisomicin, a newly developed aminoglycoside with properties similar to those of gentamicin and tobramycin, recently became available for clinical investigation (3). Initial studies demonstrated it to be highly effective in the treatment of urinary, pulmonary, and selective bacteremic infections due to gram-negative bacilli; yet in few patients with peritonitis, burn infection, or other types of wound sepsis has the antibiotic been evaluated (3). Accordingly, a clinical study of sisomicin in the management of gram-negative surgical infections was undertaken.

Keywords

Aminoglycoside Antibiotic Staph Aureus Surgical Infection Wound Sepsis Tube Dilution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bauer, A.W., Kirby, W.M.M., Sherris, J.D., and Tuck, M.: Antibiotic Susceptibility Testing by a Standardized Single Disc Method. Amer. J. Clin. Path. 45: 493, 1966.Google Scholar
  2. 2.
    Gavin, T.L., and Town, M.A.: A Microdilution Method for Antibiotic Susceptibility Testing: An Evaluation. Amer. J. Clin. Path., 53: 880, 1970.Google Scholar
  3. 3.
    Schering Corporation: Investigators Manual, Bloomfield, 1974.Google Scholar
  4. 4.
    Stone, H.H., Kolb, L.D., Geheber, C.E., and Currie, C.A.: Treatment of Surgical Infections with Tobramycin. Amer. Surg., 41: 301, 1974.Google Scholar
  5. 5.
    Winters, R.E., Litwack, K.D., and Hewitt, W.L.: Relation Between Dose and Levels of Gentamicin in Blood. J. Infect. Dis., 124: 590, 1971.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • H. H. Stone
    • 1
  • L. D. Kolb
    • 1
  • C. E. Geheber
    • 1
  1. 1.Department of SurgeryEmory University School of MedicineAtlantaUSA

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