Serum and Tissue Levels of Sisomicin in Dogs
Studies were performed on 32 beagles after a single or after seven daily intramuscular injections of 5 and 10 mg/kg sisomicin. Two dogs were used for each dose and sacrifice time. At 1 — 2 — 4 and 24 hours after the last injection the animals were sacrificed and the following fluids and tissues were taken for siso-micin determination: Serum, bile, spinal fluid, heart, lung, liver, kidney, spleen, musculature, brain, ovaries/testicles, uterus/prostate, bones, ribs, fatty tissue, adrenal glands and eyes. Antibacterial activity in varying amounts and dependent on the dose level and time was found in all the organs examined except the eyes. No difference was noted between the single or the seven dose administration at each dose level except the kidney.
KeywordsAntibacterial Activity Spinal Fluid Dose Level Adrenal Gland Tissue Level
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