Pharmacokinetics of Sisomicin in Patients with Renal Impairment

  • G. Heinecke
  • K. Finke
  • E. Renner
Part of the Chemotherapy book series (CT, volume 2)

Summary

Serum levels and urinary excretion rates of sisomicin were measured after a single i.v. injection of 1 mg/kg body wt. in 24 patients with various degrees of impaired renal function. A good correlation was found between the elimination constants and the half-lives on the one hand and creatinine clearances, serum creatinine and blood urea levels on the other hand. The retention of sisomicin increases with decreasing renal function. On the basis of these results a dosage regimen for the sisomicin therapy in patients with renal insufficiency is suggested.

Keywords

Filtration Urea Creatinine Gentamicin Glomerulonephritis 

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References

  1. Crowe,C.C. and Sanders,E. (1973), Antimicrob.Ag. and Chemother. 3, 1, 24.CrossRefGoogle Scholar
  2. Dettli,L., Spring,P., and Ryter,S. (1971), Acta Pharmacologica 29, 3, 211.Google Scholar
  3. Dost,F.H. (1968), Georg Thieme Verlag Stuttgart. Foss,S.D. (1970), Biometrics 26,4, 815.Google Scholar
  4. Gingell,J.C. and Waterworth,P.M. (1968), British Medical Journal, 2, 19.PubMedCrossRefGoogle Scholar
  5. ), Münchener Medizinische Wochenschrift 115, 39, 1657.Google Scholar
  6. Hyams,P.J., Simberkoff,M.S. and Rahal,J.J. (1973), Anti-microb.Ag. and Chemother. 3, 1, 87.CrossRefGoogle Scholar
  7. Lockwood,W.R. and Bower,J.D. (1973), Antimicrob.Ag. and Chemother. 3, 1, 125.CrossRefGoogle Scholar
  8. Stratford,B.C., Dixson,S. and Gobkoff,A.J. (1974), The Lancet 378.Google Scholar
  9. Siegenthaler,W. (1973), Georg Thieme Verlag Stuttgart.Google Scholar
  10. Waitz,J.A., Moss,E. L., Drude,C.G. and Weinstein,M.J. (1972), Antimicrob.Ag. and Chemother. 2, 6, 431.CrossRefGoogle Scholar
  11. Waitz,J.A., Moss,E.L., Oden,E.M. and Weinstein,M.J. (1970), Journal of Antibiotics 23, 11, 559.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • G. Heinecke
    • 1
  • K. Finke
    • 1
  • E. Renner
    • 1
  1. 1.Medical Clinic ICity Hospital Köln-MerheimD-5 Cologne 91Germany

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