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Bacteriological and Clinical Evaluation of Sisomicin, a New Aminoglycoside Antibiotic

  • G. F. Abbate
  • I. Alagia
  • V. Leonessa
  • P. Altucci
Part of the Chemotherapy book series (CT, volume 2)

Summary

Sisomicin exerts a high antibacterial (bactericidal) activity against Pseudomonas, most Coliform Bacilli and Staphylococcus aureus strains.

Rate of killing studies demonstrate the greater activity of Sisomicin within the first 4 hours, depending also on concentration and MBC; the effect of inoculum size on MIC of the drug is almost always very moderate.

Comparison of Sisomicin with other antibiotics show a good correlation of it with other aminoglycosides (Tobra- and Gentamicin) and some distinct advantage of Sisomicin toward other unrelated antibiotics over all for Salmonella B Wien strains.

The few resistant (or less susceptible) strains not infrequently show the lack of cross-resistance within the group.

Clinical preliminary data suggest the usefulness of Sisomicin in the treatment of gram-negative bacilli infections, over all respiratory and/or systemic also if severe or re-exacerbated.

Keywords

Brain Heart Infusion Inoculum Size Aminoglycoside Antibiotic Bacterial Titre Gentamicin Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • G. F. Abbate
    • 1
  • I. Alagia
    • 1
  • V. Leonessa
    • 1
  • P. Altucci
    • 1
  1. 1.Medical Clinic of 1st Faculty of MedicineNaples UniversityItaly

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