Bacteriological and Clinical Evaluation of Sisomicin, a New Aminoglycoside Antibiotic
Sisomicin exerts a high antibacterial (bactericidal) activity against Pseudomonas, most Coliform Bacilli and Staphylococcus aureus strains.
Rate of killing studies demonstrate the greater activity of Sisomicin within the first 4 hours, depending also on concentration and MBC; the effect of inoculum size on MIC of the drug is almost always very moderate.
Comparison of Sisomicin with other antibiotics show a good correlation of it with other aminoglycosides (Tobra- and Gentamicin) and some distinct advantage of Sisomicin toward other unrelated antibiotics over all for Salmonella B Wien strains.
The few resistant (or less susceptible) strains not infrequently show the lack of cross-resistance within the group.
Clinical preliminary data suggest the usefulness of Sisomicin in the treatment of gram-negative bacilli infections, over all respiratory and/or systemic also if severe or re-exacerbated.
KeywordsBrain Heart Infusion Inoculum Size Aminoglycoside Antibiotic Bacterial Titre Gentamicin Resistance
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