An in Vitro Comparison of Sisomicin with Gentamicin and Tobramycin
The in vitro activity of sisomicin was compared with those of gentamicin and tobramycin against 25 isolates each of Klebsiella, Enterobacter, Pseudomonas and Serratia. Kinetics of bactericidal rates were measured for 3 isolates each of the 4 genera.
Sisomicin was shown to be significantly more active than both of the other drugs against Enterobacter, Klebsiella and Serratia. Tobramycin was the most active against Pseudomonas. In terms of mean bactericidal concen. trations, sisomicin was the most active against Enterobacter and Klebsiella while tobramycin and gentamicin were the most active, respectively, against Pseudomonas and Serratia. Kinetics of bactericidal rates for the 3 drugs were similar for Enterobacter and Klebsiella; tobramycin killed Pseudomonas more rapidly than either of the other drugs. Gentamicin and tobramycin killed Serratia more rapidly than sisomicin. Significant lag periods before onset of death was observed for all three drugs with Serratia and one isolate of Pseudomonas. Evidence of populations partially resistant to sisomicin but not to the other drugs also was observed with Serratia.
KeywordsBactericidal Activity Minimal Inhibitory Concentration Active Drug Bactericidal Event Aminoglycoside Antibiotic
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