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Investigations on Circulatory Tolerance of Doxycycline (VibravenousR) and Rolitetracycline (ReverinR) in Waking Minipigs

  • G. Tauberger
  • M. Schoog
  • W. Mehren
  • G. Mergler
  • M. Moussawi
Part of the Chemotherapy book series (CT, volume 2)

Summary

The antibiotics were infused at doses of 16, 24, and 32 mg/kg over 4, 6, and 8 min, each group including 6 minipigs. After 16 mg doxycycline or rolitetracycline/kg a slight increase of the blood pressure and an extension of the P-Q interval in the ECG were observed. These changes were transient and reversible. The positively pathological P-Q interval of 160 msec was observed in none of the cases treated with doxycycline, whereas rolitetracycline led to positively pathological P-Q intervals in 2/6 of the cases and to an AV block in 4/6 of the cases. The injection of 24 and 32 mg doxycycline and rolitetracycline/kg did not lead to an increase of effect as compared with the previous tests. This is probably due to the fact that the higher doses were infused over a prolonged period of time.

Keywords

Relative Blood Volume Relative Heart Laboratory Aspect Relative Heart Weight Adequate Extension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • G. Tauberger
    • 1
    • 2
  • M. Schoog
    • 1
    • 2
  • W. Mehren
    • 1
    • 2
  • G. Mergler
    • 1
    • 2
  • M. Moussawi
    • 1
    • 2
  1. 1.Pharmacological Institute of the University of BonnGermany
  2. 2.Department for Clinical ResearchPfizer GmbH KarlsruheGermany

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