Investigations on Circulatory Tolerance of Doxycycline (VibravenousR) and Rolitetracycline (ReverinR) in Waking Minipigs
The antibiotics were infused at doses of 16, 24, and 32 mg/kg over 4, 6, and 8 min, each group including 6 minipigs. After 16 mg doxycycline or rolitetracycline/kg a slight increase of the blood pressure and an extension of the P-Q interval in the ECG were observed. These changes were transient and reversible. The positively pathological P-Q interval of 160 msec was observed in none of the cases treated with doxycycline, whereas rolitetracycline led to positively pathological P-Q intervals in 2/6 of the cases and to an AV block in 4/6 of the cases. The injection of 24 and 32 mg doxycycline and rolitetracycline/kg did not lead to an increase of effect as compared with the previous tests. This is probably due to the fact that the higher doses were infused over a prolonged period of time.
KeywordsRelative Blood Volume Relative Heart Laboratory Aspect Relative Heart Weight Adequate Extension
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