Experimental Intra-Abdominal Sepsis
Intra-abdominal sepsis usually involves multiple different bacterial species derived from the normal colonic flora. In most instances both aerobes and anaerobes are present, and the problem is to determine which of the several constituents represent true pathogens. Are these to be considered aerobic or anaerobic infections? Alternatively, there may be bacterial synergy in which both microbial types are contributing to the pathologic events. These distinctions have important implications in the area of chemotherapeutics. For practical clinical purposes, a key question concerns the necessity to treat all microbial components at the infected site. If selective antimicrobial therapy is possible, which microorganisms should receive the thrust of the attack?
KeywordsIntraabdominal Abscess Bacteroides Fragilis Hemolytic Streptococcus Neomycin Sulfate Sterile Beaker
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