Experimental Intra-Abdominal Sepsis

  • J. G. Bartlett
  • A. B. Onderdonk
  • T. Louie
  • S. L. Gorbach
Part of the Chemotherapy book series (CT, volume 2)


Intra-abdominal sepsis usually involves multiple different bacterial species derived from the normal colonic flora. In most instances both aerobes and anaerobes are present, and the problem is to determine which of the several constituents represent true pathogens. Are these to be considered aerobic or anaerobic infections? Alternatively, there may be bacterial synergy in which both microbial types are contributing to the pathologic events. These distinctions have important implications in the area of chemotherapeutics. For practical clinical purposes, a key question concerns the necessity to treat all microbial components at the infected site. If selective antimicrobial therapy is possible, which microorganisms should receive the thrust of the attack?


Intraabdominal Abscess Bacteroides Fragilis Hemolytic Streptococcus Neomycin Sulfate Sterile Beaker 


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  1. 1.
    Weinstein, W.M., Onderdonk, A.B., Bartlett, J.G., Gorbach, S.L., Experimental intra-abdominal abscess in rats: Development of an experimental model. Infect.Immunity, 10, 1250 (1974).Google Scholar
  2. 2.
    Onderdonk, A.B., Weinstein, W.M., Sullivan, N.M. Bartlett, J.G., Gorbach, S.L. Experimental intraabdominal abscesses in rats: Quantitative bacteriology of infected animals. Infect. Immunity, 10, 1256 (1974).Google Scholar
  3. 3.
    Moore, W.E.C., Holdeman, L.V. Human fecal flora; the normal flora of 20 Japanese-Hawaiian. Appl.Microbiol, 27, 961 (1974).PubMedGoogle Scholar
  4. 4.
    Anaerobe Laboratory Manual. Edited by L.V. Holdeman, W.E.C.Moore. Blacksburg. Virginia Polytechnic Institute and State University Anaerobe Laboratory (1972).Google Scholar
  5. 5.
    Edwards, P.R., Ewing, W.H. Identification of Enterobacteriaceae 3rd ed. Burgess Pub.Co., Minneapolis, Minn. (1972).Google Scholar
  6. 6.
    Weinstein, W.M., Onderdonk, A.B., Bartlett, J.B., Louis, T.E., Gorbach, S.L. Antimicrobial treatment of experimental intra-abdominal sepsis. I.Infect.Dis. (in press).Google Scholar
  7. 7.
    Winters, R.E., Litwack, K., Hewitt, W.L. Relation between dose and levels of gentamicin in blood. J.Infect.Dis.,124,Suppl. 590 (1971).Google Scholar
  8. 8.
    Alcid, D., Seligman, S.J. Simplified assay for gentamicin in the presence of other antibiotics. Antimicrob.Ag.Chemother., 3, 559, (1973).CrossRefGoogle Scholar
  9. 9.
    Tally, F.P., Jacobus, N.V., Bartlett, J.G., Gorbach, S.L. In vitro activity of penicillins against anaerobes. Antimicrobial Ag.Chem., 7, 413, (1975).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • J. G. Bartlett
    • 1
  • A. B. Onderdonk
    • 1
  • T. Louie
    • 1
  • S. L. Gorbach
    • 2
  1. 1.Infectious Disease ServiceVeterans Administration HospitalBostonUSA
  2. 2.Tufts-New England Medical CenterBostonUSA

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