Use of an in Vitro Model of the Urinary Bladder in the Investigation of Bacterial Response to Antibiotics
Conventional in vitro tests of antibacterial activity offer a simple means of assessing microbial sensitivity in the diagnostic laboratory, but the conditions of exposure of bacteria to antibiotic in such tests are remote from those encountered in vivo. In acknowledgement of this a number of experimental models have been designed utilizing laboratory animals, in which the therapeutic efficacy of new drugs or treatment regimens may be assessed. Unfortunately, animal models of infection also possess inherent limitations in terms of the treatment of human disease. One problem is that, because of anatomical and physiological differences, the conditions in which bacteria and antibiotic interact in the experimental animal differ from those encountered in man. Furthermore, it is difficult to establish the precise factors governing therapeutic efficacy in in vivo models because of their inherent complexity.
KeywordsBacterial Response Antibiotic Ampicillin Dense Bacterial Population High Urinary Level Bladder Model
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