Animal Models and Pharmacokinetics
Experimental models of human infections may help us to design treatment schedules which make more effective use of available antibacterial drugs. At the present time we determine the minimum inhibitory concentration of an antibiotic against a particular organism under conditions of steady antibiotic concentration. Yet in the treated patient the antibiotic concentration is never steady. Practical treatment schedules almost invariably involve a series of doses repeated at intervals of several hours. After each dose the concentration of antibiotic in the body fluids rises, reaches a more or less transient peak and then falls to a trough value immediately before or shortly after the next dose. We do not know how to relate the in vitro inhibitory concentration to this continuously changing antibiotic concentration in vivo.
KeywordsHalf Time Antibiotic Concentration Aminoglycoside Antibiotic Kidney Tubule Bacteriological Response
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