An Animal Model for Intestinal Infections
A model for intestinal infections with enteropathogenic bacteria in mice was established. The appropriate conditions for oral infections were achieved by alternate fasting with carbohydrate diet and sterilisation of the alimentary tract by antibiotics.
After treatment of the infected mice, the therapeutic action of various antibiotics, chemotherapeutics and various quinolines can be measured by colony counts per g bowel in comparison to that of untreated controls.
The usefulness of the model is supported by dose-dependent antibacterial effects,, by structure-activity relationship of a new class of aminonaphtoquinones and further by the successful treatment of human dysentery with the most active derivative.
KeywordsCage Ampicillin Quinone Erythromycin Chloramphenicol
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