• Lawrence R. Freedman
  • Georges Demierre
Part of the Chemotherapy book series (CT, volume 2)


Infective endocarditis has undergone a spectacular transformation since the development of antibiotics. As Lou Weinstein put it recently, “now young physicians are often disturbed by failure of defervescence within 24 – 48 hr. after initiation of treatment, and older ones are upset by a fatal outcome when, not too many years ago, they were amazed by a spontaenous recovery” (1).


Infective Endocarditis Bacterial Endocarditis Blood Culture System Streptococcus Viridans Intravenous Inoculation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    WEINSTEIN, L. and SCHLESINGER, J. Treatment of Infective Endocarditis. Progress in Cardiovasc. Dis. 16, 275, (1973).CrossRefGoogle Scholar
  2. 2.
    MANDELL, G.L. and SANDE, M.A. Some newer aspects of infective endocarditis. Geriatrics, 30, 97 (1975).PubMedGoogle Scholar
  3. 3.
    GARRISON, P.K. & L.R. FREEDMAN. Experimental endocarditis. I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J. Biol. Med. 42: 394 (1970).Google Scholar
  4. 4.
    SMITS, H. & L.R. FREEDMAN. Prolonged venous catheterization as a cause of sepsis. New Engl.J.Med. 276: 1229 (1967).CrossRefPubMedGoogle Scholar
  5. 5.
    DURACK, D.T. & P.B. BEESON. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Brit. J. Exp. Pathol. 53: 44 (1972).Google Scholar
  6. 6.
    PERLMAN, B.B. & L.R. FREEDMAN. Experimental endocarditis. III. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J. B.ol. Med. 44: 206 (1971).Google Scholar
  7. 7.
    PERLMAN, B.B. & L.R. FREEDMAN. Experimental endocarditis. III. Natural history of catheter induced staphylococcal endocarditis following catheter removal. Yale J. B.ol. Med. 44: 214 (1971).Google Scholar
  8. 8.
    FREEDMAN, L.R. & M.L. JOHNSON. Experimental endocarditis. IV. Tricuspid and aortic valve infection with Candida albicans in rabbits. Yale J. Biol. Med. 45: 163 (1972).Google Scholar
  9. 9.
    J. CARRIZOSA, C. KOHM and M.E. LEVINSON. Experimental Aspergillus Endocarditis in Rabbits. Clinical Research 22, 438 A (1974).Google Scholar
  10. 10.
    VALONE, J. and L.R. FREEDMAN. In preparation (1974).Google Scholar
  11. 11.
    DURACK, D.T., P.B. BEESON & R.G. PETERSDORF. Experimental bacterial endocarditis. III. Production and progress of the disease in rabbits. Brit. J. Exp. Pathol. 54: 142 (1973).Google Scholar
  12. 12.
    LINNEMAN, C.C., Jr., C. WATANAKUNAKORN & C. BAKIE. Studies on the pathogenicity of stable L-phase variants of Staphylococcus aureus. Failure to colonize experimental endocarditis in rabbits. Infec. Immunity 7: 725 (1973).Google Scholar
  13. 13.
    DURACK, D.T. Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J. Path. 115, 81 (1975).CrossRefPubMedGoogle Scholar
  14. 14.
    HOOK, E.W. III and Sande, M.A. Role of the vegetation in experimental Streptococcus viridans endocarditis. Infection and Immunity 10, 1433 (1974).PubMedGoogle Scholar
  15. 15.
    DURACK, D.T. & P.B. BEESON. Experimental bacterial endocarditis. II. Survival of bacteria in endocardial vegetations.Brit. J. Exp. Pathol. 53: 50 (1972).Google Scholar
  16. 16.
    FREEDMAN, L.R., ARNOLD, S., VALONE, J. Experimental endocarditis. Annals N.Y. Acad. Sci. 236, 456 (1974).CrossRefGoogle Scholar
  17. 17.
    ARNOLD, S.B., VALONE, J.A., ASKENASE, P.W., KASHGARIAN, M. and FREEDMAN, L.R. Diffuse Glomerulonephritis in Rabbits with Streptococcal Viridans Endocarditis. Lab. Invest. 1975 in press.Google Scholar
  18. 18.
    R.A. JOYCE and M.A. SANDE. Mechanism of Anemia in Experimental Bacterial Endocarditis. Clinical Research 22,396 A (1974).Google Scholar
  19. 19.
    DEMIERRE, G., VALONE, J. and FREEDMAN, L.R.In preparation.Google Scholar
  20. 20.
    McGOWAN, D.A. and HARDIE, J.M. Brit. Dent.J. 137, 129 (1975).Google Scholar
  21. 21.
    BAHN, S.L., BITTERMAN, P., ROSS, D. and BAHN, A.N. J. Dent. Res. 54, L 101 (1975).Google Scholar
  22. 22.
    D. TANPHAICHITRA, K., RIES, M.E. LEVISON. Clinical Research, 22, 455 A (1974).Google Scholar
  23. 23.
    J.W. EAKINS. Rabbit Endocarditis Model to test the Effectiveness of Five Blood Culture Systems. Clinical Research 23, 27 A (1975).Google Scholar
  24. 24.
    DURACK, D.T. & R.G. PETERSDORF. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J. Clin. Invest. 52: 592 (1973).CrossRefPubMedGoogle Scholar
  25. 25.
    SOUTHWICK, F.S. and DURACK, D.T. Chemotherapy of experimental streptococcal endocarditis. III. F.ilure of a bacteriostatic agent (tetracycline) in prophylaxis. J. Clin. Path. 27, 261 (1974).CrossRefPubMedGoogle Scholar
  26. 26.
    DURACK, D.T. and LITTLER, W.A. Failure of “adequate” penicillin therapy to prevent bacterial endocarditis after tooth extraction. Lancet 2, 846 (1974).CrossRefPubMedGoogle Scholar
  27. 27.
    ARNOLD, S., DEMIERRE, G. and FREEDMAN, L.R.In preparation.Google Scholar
  28. 28.
    DEMIERRE, G. and FREEDMAN, L.R. In preparation.Google Scholar
  29. 29.
    L.L. PELLETIER, K. NIELSON, R.G. PETERSDORF. Dynamics of Infection and Response to treatment of streptococcus Sanguis Experimental Endocarditis. Clin. Research 23, 416 A (1975).Google Scholar
  30. 30.
    SANDE, M.A. & R.G. IRVIN. Penicillin aminoglycoside therapy in experimental endocarditis. J. Inf. Dis. 129: 572 (1974).CrossRefGoogle Scholar
  31. 31.
    SANDE, M.A. & M.L. JOHNSON. Antibiotic therapy of experimental endocarditis caused by staphylococcus aureus. J. Inf. Dis. 131: 367 (1975).CrossRefGoogle Scholar
  32. 32.
    DURACK, D.T., PELLETIER, L.L., PETERSDORF, R.G. Chemotherapy of experimental streptococcal endocarditis. II. Synergism between penicillin and streptomycin against penicillin-sensitive streptococci. J. Clin. Invest. 53, 829 (1974).CrossRefPubMedGoogle Scholar
  33. 33.
    J. CARRIZOSA, D. KAYE. Choice of aminoglycoside in Enterococcal Endocarditis. Clin. Res. 23, 415 A (1975).Google Scholar
  34. 34.
    J. CARRIZOSA and M.E. LEVISON. Minimal Concentrations of Ammoglycoside for Synergy Against Enterococci.Clinical Research 23, 301 A (1975).Google Scholar
  35. 35.
    E.W. HOOK III, R.B. ROBERTS, M.A. SANDE. Antimicrobial Therapy of Experimental Enterococcal Endocarditis.Clinical Research 23, 305 A (1975).Google Scholar
  36. 36.
    CARRIZOSA, J., KOBASA, W.D. and KAYE, D. Antagonism Between Chloramphenicol and Penicillin in Streptococcal Endocarditis in Rabbits. J. Lab. Clin. Med. 85: 307 (1975).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Lawrence R. Freedman
    • 1
  • Georges Demierre
    • 1
  1. 1.Department of Internal Medicine Centre Hospitalier Universitaire VaudoisUniversity of LausanneSwitzerland

Personalised recommendations