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Intraperitoneal Challenge

  • K. R. Comber
  • C. D. Osborne
  • R. Sutherland
Part of the Chemotherapy book series (CT, volume 2)

Abstract

Experimental intraperitoneal mouse infections are used universally in the assessment of the therapeutic potential of novel antibacterial agents and in the majority of cases the virulence of the infecting organism is enhanced by the concomitant administration of hog gastric mucin to the animal. Much effort has been devoted to studies of the preparation, biological mode of action, and active constituents of hog gastric mucin and there is a considerable body of knowledge concerning these aspects, as can be seen from the excellent reviews of Olitski (1948, 1957). Surprisingly, there appears to have been much less study of the effects of therapy on the development of the intraperitoneal infection in the animal host, despite the extensive use of these routine tests in the evaluation of compounds.

Keywords

Intraperitoneal Injection Peritoneal Cavity Bacterial Count Active Constituent Rapid Appearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Olitski,L.,1948.Bacteriological Reviews, 12, 149.Google Scholar
  2. Olitski,L.,1957.Bulletin of the Research Council of Israel,6E,193.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • K. R. Comber
    • 1
  • C. D. Osborne
    • 1
  • R. Sutherland
    • 1
  1. 1.Beecham Pharmaceuticals Research DivisionBetchworth, SurreyEngland

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