Animal Models in the Assessment of Antimicrobial Agents: What should We Expect of Them?

  • Francis O’Grady
Part of the Chemotherapy book series (CT, volume 2)


The properties required of an effective therapeutic antibiotic are few in number but demanding in character. The agent must be absorbed from the site of administration and survive the processes of metabolic destruction and excretion to the extent that it reaches the site of infection in sufficient concentration to inhibit the growth of bacteria or better still to kill them.


Antimicrobial Agent Antibacterial Effect Human Infection Experimental Infection Antibiotic Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Francis O’Grady
    • 1
  1. 1.Department of Microbiology City HospitalUniversity of NottinghamNottinghamUK

Personalised recommendations