Animal Models in the Assessment of Antimicrobial Agents: What should We Expect of Them?
The properties required of an effective therapeutic antibiotic are few in number but demanding in character. The agent must be absorbed from the site of administration and survive the processes of metabolic destruction and excretion to the extent that it reaches the site of infection in sufficient concentration to inhibit the growth of bacteria or better still to kill them.
KeywordsAntimicrobial Agent Antibacterial Effect Human Infection Experimental Infection Antibiotic Concentration
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