The Problem of Antibiotic Mixtures in Serum Samples
The treatment of bacterial infection by the giving of more than one antibiotic simultaneously is a common and frequently justifiable practice. Clinical microbiological laboratories are therefore often faced with the problem of assaying an antibiotic in a sample of body fluid in the presence of one or more other antibiotics. Even when the antibiotics are given sequentially as treatment the residual presence of an antibiotic which has ceased being administered can prove an unexpected hazard to accurate assay. Microbiological assays are the commonest method used in clinical laboratories and although convenient they are usually lacking in specificity. This review will explore methods of increasing the specificity of microbiological assays and also briefly examine other more specific assays suitable for serum samples.
KeywordsCephal Exin Specific Assay Fusidic Acid Aminoglycoside Antibiotic Semi Carbazide
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