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Trimethoprim and Rifampicin: In Vitro Activities Separately and in Combination

  • D. W. Kerry
  • J. M. T. Hamilton-Miller
  • W. Brumfitt
Part of the Chemotherapy book series (CT, volume 2)

Abstract

Rifampicin (rif) and trimethoprim (tm) are familiar broad-spectrum oral antimicrobial agents. Both drugs owe their antibacterial activity primarily to their effect on the biosynthesis of nucleic acids. Their target sites may thus be regarded as occurring on the same metabolic pathway; sequential blockade of a metabolic pathway has been shown to result in a potentially synergistic situation. Consequently, we tested rif and tm in combination, to investigate possible antibacterial interactions.

Keywords

Bacteroides Fragilis Royal Free Hospital Klebsiella Aerogenes Streptococcal Strain Pathogenic Bacterial Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • D. W. Kerry
    • 1
  • J. M. T. Hamilton-Miller
    • 1
  • W. Brumfitt
    • 1
  1. 1.The Royal Free HospitalLondonUK

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