Brief Antibiotic Exposure and Effect on Bacterial Growth

  • P. J. McDonald
  • W. A. Craig
  • C. M. Kunin
Part of the Chemotherapy book series (CT, volume 2)


The effects of Staph.aureus and E.coli of 0.5 to 4 hrs antibiotic treatment have been examined. A period of growth suppression after removal of antibiotic from broth cultures was documented with penicillin, ampicillin, cephalothin, erythromycin, tetracycline, and clindamycin. This post-antibiotic effect was related to time of treatment with the penicillins, erythromycin and clindamycin.

Increasing penicillin concentration beyond .05 mcg/ml failed to prolong post-antibiotic suppression whereas a dose-related effect was observed with erythromycin and clindamycin. Persistent effect of gentamicin could not be demonstrated.


Viable Count Persistent Effect Antibiotic Exposure Lower Graph Present Study Document 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • P. J. McDonald
    • 2
  • W. A. Craig
    • 1
  • C. M. Kunin
    • 1
  1. 1.Department of MedicineUniversity of Wisconsin and Veterans Administration HospitalMadisonUSA
  2. 2.Flinders University School of MedicineBedford ParkSouth Australia

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