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Brief Antibiotic Exposure and Effect on Bacterial Growth

  • P. J. McDonald
  • W. A. Craig
  • C. M. Kunin
Part of the Chemotherapy book series (CT, volume 2)

Summary

The effects of Staph.aureus and E.coli of 0.5 to 4 hrs antibiotic treatment have been examined. A period of growth suppression after removal of antibiotic from broth cultures was documented with penicillin, ampicillin, cephalothin, erythromycin, tetracycline, and clindamycin. This post-antibiotic effect was related to time of treatment with the penicillins, erythromycin and clindamycin.

Increasing penicillin concentration beyond .05 mcg/ml failed to prolong post-antibiotic suppression whereas a dose-related effect was observed with erythromycin and clindamycin. Persistent effect of gentamicin could not be demonstrated.

Keywords

Viable Count Persistent Effect Antibiotic Exposure Lower Graph Present Study Document 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • P. J. McDonald
    • 2
  • W. A. Craig
    • 1
  • C. M. Kunin
    • 1
  1. 1.Department of MedicineUniversity of Wisconsin and Veterans Administration HospitalMadisonUSA
  2. 2.Flinders University School of MedicineBedford ParkSouth Australia

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