Brief Antibiotic Exposure and Effect on Bacterial Growth
The effects of Staph.aureus and E.coli of 0.5 to 4 hrs antibiotic treatment have been examined. A period of growth suppression after removal of antibiotic from broth cultures was documented with penicillin, ampicillin, cephalothin, erythromycin, tetracycline, and clindamycin. This post-antibiotic effect was related to time of treatment with the penicillins, erythromycin and clindamycin.
Increasing penicillin concentration beyond .05 mcg/ml failed to prolong post-antibiotic suppression whereas a dose-related effect was observed with erythromycin and clindamycin. Persistent effect of gentamicin could not be demonstrated.
KeywordsViable Count Persistent Effect Antibiotic Exposure Lower Graph Present Study Document
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