Brief Antibiotic Exposure and Effect on Bacterial Growth
The effects of Staph.aureus and E.coli of 0.5 to 4 hrs antibiotic treatment have been examined. A period of growth suppression after removal of antibiotic from broth cultures was documented with penicillin, ampicillin, cephalothin, erythromycin, tetracycline, and clindamycin. This post-antibiotic effect was related to time of treatment with the penicillins, erythromycin and clindamycin.
Increasing penicillin concentration beyond .05 mcg/ml failed to prolong post-antibiotic suppression whereas a dose-related effect was observed with erythromycin and clindamycin. Persistent effect of gentamicin could not be demonstrated.
KeywordsPenicillin Turbidity Ampicillin Tetracycline Gentamicin
Unable to display preview. Download preview PDF.
- 2.Eagle, H., Fleischman, R., Levy, M. (1953) “Continuous” vs “Discontinuous” therapy with penicillin; effect of interval between injections on therapeutic efficiency. New England J.Med., 248, 481.Google Scholar
- 3.Parker, R.F., Luse, S. (1948) The action of penicillin on Staphylococcus: Further observations on effect of short exposure. J.Bacteriol., 56, 75.Google Scholar
- 4.Parker, R.F., Marsh, M.C. (1946) The action of penicillin on Staphylococcus. J.Bacteriol., 51, 181.Google Scholar
- 6.Washington, J.A., Barry, A.L. (1974) “Dilution test procedures” in Manual of Clinical Microbiology, 2nd ed. Editors Lenette, E.H., Spalding, E.H., Truant, J.P. Published by American Society of Microbiology, Washington, D.C., 410.Google Scholar
- 7.Weisblum, B., Davies, J. (1968) Antimicrobial inhibitors of the bacterial ribosome. Bact.Rev., 32, Suppl. 493.Google Scholar