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Thymidine and the Assessment of Co-Trimoxazole Action in Liquid Media

Part of the Chemotherapy book series (CT, volume 2)

Summary

Thymidine and thymine contents in human blood and urine seem to be too low to interfere with the bactericidal activity of co-trimoxazole, (sulphamethoxazole/trimethoprim), observed in vitro in thymidine-free media. Most of the commercially available liquid media contain high thymidine concentrations which prevent a bactericidal action and are not suitable for testing purposes. Although the addition of 5% lysed blood converts the thymidine in those media very effectively into thymine, many media remain unsatisfactory since the relatively high thymine concentrations generated also antagonize a bactericidal action.

Keywords

Nutrient Broth Folinic Acid Thymidine Phosphorylase Testing Purpose Aminobenzoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bushby, S.R.M. (1973), J. Inf. Dis., 128 Suppl., 442.Google Scholar
  2. Ferone, R., Bushby, S.R.M., Burchall, J.J., Moore, W.D. and Smith, D. (1975), Antimicrob. Ag. Chemother., 7, 91.Google Scholar
  3. Then, R. and Angehrn, P. (1974), Biochem. Pharmacol., 23, 2977.PubMedCrossRefGoogle Scholar
  4. Then, R. and Angehrn, P. (1975), Biochem. Pharmacol., 24, 1003.PubMedCrossRefGoogle Scholar
  5. Waterworth, P. (1969), Postgrad. Med. J., Suppl. Vol. 45, 21.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • R. Then
    • 1
  1. 1.Department of Experimental MedicineF. Hoffman-La, Roche & Co. Ltd.BasleSwitzerland

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