Metazoan Mesenchyme Partitions the Extracellular Space During Matrix Morphogenesis

  • David E. Birk
  • Robert L. Trelstad
Part of the NATO ASI Series book series (NSSA, volume 93)


The interstitial space of metazoans is occupied by fixed and diffusible molecules of a variety of sizes and shapes which serve as the substratum for local cells and the scaffold for the tissue as a whole. The deposition of matrix components such as the collagens involves multiple steps which begin within specific compartments inside the cell and continue in specific compartments outside the cell. The passage of matrix components from the intracellular compartments to the extracellular compartments is a continuum, temporally, functionally and spatially. Analysis of 0.5 to 1.0 μm thick epoxy embedded sections of young fibroblasts from embryonic chick tendon and cornea with the high voltage (1000 kv) transmission electron microscope has led to an expanded understanding of the multiple compartments formed inside and outside the fibroblast and how these compartments relate to collagen fibrillogenesis, fibril bundle formation and tissue morphogenesis.


Collagen Fibril Extracellular Compartment High Voltage Electron Specific Compartment Bundle Formation 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • David E. Birk
    • 1
  • Robert L. Trelstad
    • 1
  1. 1.Department of Pathology Rutgers Medical SchoolUniversity of Medicine and Dentistry of New JerseyPiscatawayUSA

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