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Collagens Immunotyping

  • Jean-Alexis Grimaud
  • Michel Druguet
  • Hervé Emonard
  • Simone Peyrol
  • Claire-Marie Barioz
  • Sylviane Guérret
Part of the NATO ASI Series book series (NSSA, volume 93)

Abstract

Collagens are the main structural proteins of vertebrate and invertebrate extracellular matrix (ECM). The ECM results from the association of different collagens named collagen isotypes biochemically and morphologically distinct, each one being characterized by genetically distinct polypeptide α-chains (table I -for review see Timpl, 1976; Beard et al., 1977). Selective codistribution of collagen types (interstitial and basement membrane collagens) with associated proteins defines distinct micro-anatomical compartments inside ECM. These compartments are always present as interactive sites between epithelial and mesenchymal areas. The polymorphic aspect of ECM reflects a large variety of specific macromolecular associations requiring special analyses: those proposed in the present work are based on the immunochemical properties of collagen molecules.

Keywords

Collagen Type Human Collagen Nitrocellulose Sheet Collagen Antibody Fixation Wash 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jean-Alexis Grimaud
    • 1
  • Michel Druguet
    • 1
  • Hervé Emonard
    • 1
  • Simone Peyrol
    • 1
  • Claire-Marie Barioz
    • 1
  • Sylviane Guérret
    • 1
  1. 1.Institut PasteurLyonFrance

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