The Interstitial Collagens of Fish

  • Shigeru Kimura
Part of the NATO ASI Series book series (NSSA, volume 93)


Lower vertebrates including cyclostomes, chondrichthyes and osteichthyes are usually referred to as fish. They are Poikilothermic and are to be found in the wider range of habitats from below zero to over 50°C, The collagenous proteins of fish, as well as mammals, are widely distributed in skin, cartilage, bone and many other organs. About 30 years ago, studies of fish had contributed substantially to our understanding of the macromolecular structure of collagen, because their connective tissues have some unique properties. First, the skin and swim bladder collagens of fish are extremely soluble in dilute acid to yield a large amount of soluble protein; this provides a good source for the structural study of collagen molecules in solution. Perhaps the carp swim bladder collagen, which was called “ichthyocol”, was the first soluble collagen to be fully characterized with respect to its molecular weight and molecular dimensions in native and denatured states (Boedtker and Doty, 1956). At present, the basic macro-molecular structure of interstitial collagens is considered to be common to all vertebrate species.


Skin Type Collagen Molecule Difference Index Bony Fish Cyanogen Bromide 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Shigeru Kimura
    • 1
  1. 1.Laboratory of BiochemistryTokyo University of FisheriesMinato-ku, TokyoJapan

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