Collagen Families — Evolutionary Adaptation of Molecular and Macromolecular Structures to Physiological Function

  • Klaus Kühn
  • Rupert Timpl
Part of the NATO ASI Series book series (NSSA, volume 93)


According to the manifold physiological functions, connective tissue appears in a variety of different forms. They are characterized by specific macromolecular organizations whose formation is controlled by different collagen types. The type specific scaffolds of collagen, in which other extracellular matrix components are embedded, are responsible for the structure as well as for the biochemical properties of connective tissue. At present, three different collagen families are known, which differ in their molecular and macromolecular structures. These are the fiber forming collagens, the network forming collagens and the filamentous collagens.


Triple Helix Extracellular Matrix Component Globular Domain Macromolecular Structure Hydrophobic Amino Acid Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. Nordwig and V. Hayduk, Invertebrate collagens: isolation, characterization and phylogenetic aspects, J. Molec. Biol. 44:161 (1969)CrossRefGoogle Scholar
  2. 2.
    I. Oberbäumer, H. Wiedemann, R. Timpl, and K. Kühn, Shape and assembly of type IV procollagen obtained from cell culture, Embo J. 1:805 (1982).Google Scholar
  3. 3.
    R. Timpl, H. Wiedemann, V. van Delden, H. Furthmayr, and K. Kühn, A network model for the organization of the type IV collagen in basement membranes, Eur. J. Biochem. 120:203 (1981)CrossRefGoogle Scholar
  4. 4.
    J.H. Fessier, H.P. Bächinger, G. Lunstrum, and L.I. Fessier, Biosynthesis and processing of some procollagens, in: “New Trends in Basement Membrane Research”, K. Kühn, H. Schöne, and R. Timpl, eds, Raven Press, New York (1982).Google Scholar
  5. 5.
    K. Furthmayr, H. Wiedemann, R. Timpl, E. Odermatt, and J. Engel, Electron-microscopical approach to a structural model of intima collagen, Biochem. J. 211:301 (1983).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Klaus Kühn
    • 1
  • Rupert Timpl
    • 1
  1. 1.Max-Planck- Institut für BiochemieMartinsriedGermany

Personalised recommendations