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Early Chemical Events and Initial DNA Damage

  • Aloke Chatterjee
  • William R. Holley
Part of the Basic Life Sciences book series (BLSC, volume 58)

Abstract

Early chemical events (between 10−15 and 10−6 seconds) as they relate to the evolution of damage in radiation biology have been described in terms of a theoretical model. DNA is the target of concern in this model, and both indirect and direct effects have been explicitly accounted for in evaluating yields of strand breaks. In the indirect-effect considerations, a quantitative estimation of the time decay of water radical species—beginning with their production at 10−14 seconds and leading to the interactions of hydroxyl radicals with DNA—has been a major focus. A method based on stopping-power theory and the Bragg rule has been described to account for direct effects. However, no attempt is made to follow all the chemical events that take place between the creation of initial (10−6 seconds) damage and the observable strand break yields. The theoretical calculations refer to a simple aqueous system containing DNA molecules and scavenger (Tris). The theoretical results of strand break yields by different heavy charged particles are in good agreement with experimental cellular data under conditions of minimal enzymatic repair.

Keywords

Strand Break Energy Deposition Linear Energy Transfer Radiation Chemistry Water Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Aloke Chatterjee
  • William R. Holley
    • 1
  1. 1.Division of Cell and Molecular Biology, Lawrence Berkeley LaboratoryUniversity of California at BerkeleyBerkeleyUSA

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