Abstract
Intense interest in serotonin (5-hydroxytryptamine, 5-HT) stems from the involvement of this biogenic amine in an extraordinary range of physiological functions. (See, for example, the five-volume series edited by Essman, 1977–1979.) Most tissues and organs are affected by 5-HT, either through serotonergic neurons or following its release from blood platelets and other non-neuronal sites. Both platelets and serotonergic neurons have mechanisms for the active uptake of 5-HT, and the platelet has become a model for studying aspects of the regulation of 5-HT levels. The discovery that platelets of endogenously depressed patients have a decreased number of high-affinity binding sites for [3H]-imipramine (Briley et al., 1980; Paul et al., 1981) has kindled research on the imipramine binding site, and this site is now thought to effect a modulation of 5-HT uptake (Wennogle and Meyerson, 1983, 1985; Meyerson et al., submitted).
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© 1987 Plenum Press, New York
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Walton, K.G. et al. (1987). “Substance M”, A Serotonin Modulator Candidate from Human Urine?. In: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., Berry, W.O. (eds) Molecular Mechanisms of Neuronal Responsiveness. Advances in Experimental Medicine and Biology, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7618-7_36
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