Potassium Channels in Mouse Spinal Cord Cells

  • J. E. Kimura
  • B. McIver
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 221)


Activation of voltage gated potassium channels is important for the repolarization of the action potential in a number of systems (for example, the squid giant axon: Hodgkin and Huxley, 1952b; and the frog node of Ranvier: Stampili and Hille, 1976), though it may not be necessary in others (mammalian node of Ranvier: Chiu, Ritchie, Rogart and Stagg, 1979). Barrett, Barrett and Crill (1980) reported the existence of both fast and slow voltage-activated outward currents in cat motor neurones in vivo, and suggested that the fast component may be involved in repolarization of the fast action potential. However, iontophoretic application of tetra-ethyl ammonium (TEA), sufficient to reduce the amplitude of this fast outward current, caused only a minor increase in the duration of the action potential (Schwindt and Crill, 1980; Schwindt and Crill, 1981).


Single Channel Outward Current Voltage Gated Potassium Channel Single Channel Current Mouse Spinal Cord 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. E. Kimura
    • 1
  • B. McIver
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of VermontBurlingtonUSA

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