Altered Reactivity of the Rat Adrenal Medulla Following Periods of Chronic Stress

  • J. P. Mitchell
  • P. R. Vulliet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 221)


The chromaffin cells of the adrenal medulla are derived from embryonic neural tissues; specifically, the neural crest cells. These cells share many biochemical and functional properties with adrenergic neurons and are a useful model for studying many of the biochemical processes that occur in adrenergic neurons. These cells are known to be responsive to a variety of agonists and antagonists that also modulate sympathetic neuronal activity, contain the proteins necessary for the synthesis and release of the catecholamine neurotransmitters, and respond to growth factors that are known to regulate adrenergic growth. This tissue also contains several putative neurotransmitters and neurally active peptides. The primary physiological function of the chromaffin cells is to release epinephrine and norepinephrine in response to acetylcholine released from the preganglionic neuron.


Adrenal Gland Tyrosine Hydroxylase Chromaffin Cell Adrenal Medulla Immobilization Stress 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. P. Mitchell
    • 1
  • P. R. Vulliet
    • 1
  1. 1.Department of PhysiologyColorado State UniversityFort CollinsUSA

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