Long-Term Inhibition of Kindled Seizures by Chemical and Electrophysiological Techniques: Insights into the Kindling Process?
The kindling phenomenon is frequently called a model of epilepsy but is more correctly a model of epileptogenesis. It is also a model for neuronal plasticity. For almost 20 years now, ever increasing numbers of neuroscientists have been fascinated by the fact that daily administration of a mild electrical stimulus which is initially without effect will lead to a progressive intensification of response culminating in a seizure. The importance of this phenomenon was first recognized by Goddard (1967) and the study of kindling by Goddard et al. (1969) remains the pivotal point in this area. Goddard (1967) used the term kindling as an analogy with the kindling or lighting of a fire. Strictly speaking, the kindling of a fire is not a good analogy for the process. However, the term now has the advantage of familiarity and certainly no other commonplace occurance suggests a closer analogy.
KeywordsSeizure Activity Audiogenic Seizure Myoclonic Seizure Motor Seizure Pentylene Tetrazole
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