Abstract
The great complexity of the central nervous system makes it a difficult object of biochemical study. Yet, some of the most important biochemical discoveries having implications for the field of cell regulation have been made in CNS tissue. A case in point is the discovery by Nishizuka and coworkers of a new kind of protein kinase, the so-called phospholipid-dependent, calcium-activated protein kinase or C-kinase, in brain tissue (Takai et al.). This kinase was found to be distinct from either the classic cAMPdependent or Ca++-CaM-dependent protein kinases. It was, however, found to be activated by Ca++, phospholipids, and diacylglycerols (Takai et al., 1977; Kishimoto et al., 1980). After its discovery in the brain, where it exists in very large amounts, it was found to be widely distributed in animal tissues (Nishizuka and Takai, 1981). Its discovery coincided in time with a significant breakthrough in our understanding of the role of inositol polyphosphatase in the transducing events which occur in the calcium messenger system (Michell, 1975; Berridge, 1984) (see chapters by Agranoff and by Lapetina in this volume).
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Rasmussen, H., Barrett, P. (1987). Temporal and Spatial Events in the Calcium Messenger System. In: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., Berry, W.O. (eds) Molecular Mechanisms of Neuronal Responsiveness. Advances in Experimental Medicine and Biology, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7618-7_2
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DOI: https://doi.org/10.1007/978-1-4684-7618-7_2
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