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Tyrosine Availability: A Presynaptic Factor Controlling Catecholamine Release

  • J. D. Milner
  • R. J. Wurtman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 221)

Abstract

Considerable evidence has been available for many years that low doses of exogenous tryptophan, which elevate brain tryptophan but keep its levels within their normal range, can increase brain serotonin and 5-hydroxyindoleacetic acid concentrations (Wurtman and Fernstrom, 1976; Fernstrom and Wurtman, 1971). Moreover, food consumption had been shown some years ago to influence brain tryptophan, and thereby brain serotonin levels, with carbohydrate-rich meals increasing (Fernstrom and Wurtman, 1971) and protein meals decreasing (Fernstrom and Wurtman, 1972) serotonin synthesis, and it has been proposed that this coupling of food composition to serotonin synthesis allows serotonin-dependent behaviors to be affected by eating (Fernstrom and Wurtman, 1974; Young, 1983).

Keywords

Tyrosine Hydroxylase Large Neutral Amino Acid Catecholamine Synthesis Dopaminergic Terminal Tyrosine Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. D. Milner
    • 1
  • R. J. Wurtman
    • 1
  1. 1.Department of Brain and Cognitive SciencesMassachusetts Institute of TechnologyCambridgeUSA

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