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Regulation of Neuronal Adenylate Cyclase

  • M. M. Rasenick
  • M. M. Marcus
  • Y. Hatta
  • F. DeLeon-Jones
  • S. Hatta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 221)

Abstract

Receptors for a panoply of neurotransmitters and neuromodulators are known to couple to the adenylate cyclase system. In the past few years we have benefitted from an explosion of information concerning the molecular identification of the adenylate cyclase components, and this information has served both to elucidate possible mechanisms for the coupling of adenylate cyclase to receptors as well as the activation cascade of that enzyme. This information has also served to illustrate the extraordinary complexity of the system. Several recent reviews (cf. Birnbaumer et al., 1985; Gilman, 1984) have addresssed the structure and function of adenylate cyclase. The purpose of this manuscript is not to overlap with those, but rather, to illustrate some of the unusual features of adenylate cyclase from neural systems.

Keywords

Adenylate Cyclase Adenylate Cyclase Activity Synaptic Membrane Adenylate Cyclase System Basal Adenylate Cyclase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ali, I. and Hynes, R., Biochem. Biophysics Acta 471:16–23 (1977).CrossRefGoogle Scholar
  2. Anderson, P., Klysner, R., Geisler, A., Neuropharmacol. 23:445–447 (1984).CrossRefGoogle Scholar
  3. Bell, J. O., Buxton, I. and Brunton, L., J. Biol. Chem. 260:2625–2628 (1985).Google Scholar
  4. Birnbaumer, L., Codina, J., Mattera, R., Cerione, R., Hildebrandt, J., Sunyer, T., Rojas, F., Caron, M., Lefkowitz, R., Iyengar, R., Molecular Mechanisms of Transmembrane Signalling. Editors, Cohen & Houslay (Elsevier-Amsterdam) (1985).Google Scholar
  5. Bitensky, M. W., Wheeler, M. A., Rasenick, M. M., Yamazaki, A., Stein, P., Halliday, K. and Wheeler, G., Proc. Natl. Acad. Sci. (USA) 79:3408–3412 (1982).CrossRefGoogle Scholar
  6. Cerione, R. A., Regan, J. W., Nakata, H., Codina, J., Benovic, J. L., Gierschik, P., Somers, R. L., Spiegel, A. M., Birnbaumer, L., Lefkowitz, R. J. and Caron, M.G., J. Biol. Chem. 261(8):3901–3909 (1986).Google Scholar
  7. Cerione, R. A., Staniszawski, C., Benovic, J., Lefkowitz, R., Caron, M., Gierschik, P., Somers, R., Spiegel, A., Codina, J. and Birnbaumer, L., J. Biol. Chem. 260:1493–1500 (1985).Google Scholar
  8. Childers, S. and LaRivere, G., J. Neuroscience 4:2764–2771 (1984).Google Scholar
  9. Codina, J., Hildebrandt, J., Sunyer, T., Sekura, R. D., Manclark, C. R., Iyengar, R. and Birnbaumer, L., Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17:111–125 (1984).Google Scholar
  10. D’Alayer, J., Berthilliar, G. and Monneron, A., Biochemistry 22:3948–3953 (1983).CrossRefGoogle Scholar
  11. Evans, T., Martin, M., Hughes, A. and Harden, T. K., Mol. Pharm. 27:32–37 (1985).Google Scholar
  12. Florio, V. A. and Sternweis, P. C., J. Biol. Chem. 260(6):3477–3483 (1985).Google Scholar
  13. Gilman, A. G., J. Cell 36:577–579 (1984).CrossRefGoogle Scholar
  14. Halliday, K., J. Cyclic Nucleo. Prot. Phos. Res. 9:435–448 (1984).Google Scholar
  15. Hatta, S., Marcus, M. M. and Rasenick, M. M., Proc. Natl. Acad. Sci. (USA) 83:5439–5443 (1986).CrossRefGoogle Scholar
  16. Hughes, A., Martin, M. and Harden, T. K., Proc. Natl. Acad. Sci. (USA) 81: 5680–5684 (1984).CrossRefGoogle Scholar
  17. Insel, P. A. and Kennedy, M. S., Nature 273(5662):471–473 (1978).CrossRefGoogle Scholar
  18. Katada, T., Bokoch, G. M., Northup, J. K., Ui, M. and Gilman, A. G., J. Biol. Chem. 259:3568–3585 (1984).Google Scholar
  19. Lim, L., Sekura, R. and Kaslow, H. J., J. Biol. Chem. 260:2585–2588 (1985).Google Scholar
  20. Limbird, L. E., Gill, D. M. and Lefkowitz, R. J., Proc. Natl. Acad. Sci. USA 77:775–779 (1980).CrossRefGoogle Scholar
  21. Menkes, D., Rasenick, M. M., Wheeler, M. A. and Bitensky, M. W., Science 219:65–67 (1983).CrossRefGoogle Scholar
  22. Neer, E. J., Lok, J. M. and Wolf, L. G., J. Biol. Chem. 259:14222–14229 (1984).Google Scholar
  23. Nijjar, M. S. and Ho, J. C., Biochem. Biophys. Acta. 600(1):238–243 (1980).CrossRefGoogle Scholar
  24. Northup, J. K., Smigel, M. D. and Gilman, A. G., J. Biol. Chem. 257:11416–11423 (1982).Google Scholar
  25. Perkins, J. P., Adv. Cyclic Nucleo. Res. 3:1–64 (1973).Google Scholar
  26. Rasenick, M. M. and Bitensky, M. W., Proc. Natl. Acad. Sci. (USA) 77:4628–4632 (1980).CrossRefGoogle Scholar
  27. Rasenick, M. M., O’Callahan, C. M., Moore, C. A. and Kaplan, R. S., In: Microtubules and Microtubule Inhibitors eds. M. De Brabander and J. DeMey (Elsevier Amsterdam), pp. 313–323 (1985).Google Scholar
  28. Rasenick, M. M., Stein, P. J. and Bitensky, M. W., Nature 294:6560–6562 (1981).CrossRefGoogle Scholar
  29. Rasenick, M. M., Valley, S., Manuelidis, E. E. and Manuelidis, L. FEBS Lett. 198:164–168 (1986).CrossRefGoogle Scholar
  30. Rasenick, M. M., Wheeler, G. L., Bitensky, M. W., Kosack, C., Maling, R. L. and Stein, P. J., J. Neurochem. 43:1447–1454 (1984).CrossRefGoogle Scholar
  31. Rudolph, S. A., Greengard, P. and Malawista, S. E., Proc. Natl. Acad. Sci. (USA) 74:3404–3408 (1977).CrossRefGoogle Scholar
  32. Schlegel, W., Kempner, E. and Rodbell, M. D., J. Biol. Chem. 254:5168–5176 (1979).Google Scholar
  33. Schulman, H., In: Microtubules and Microtubule Inhibitors eds. M. De Brabander and J. DeMey (Elsevier Amsterdam) pp. 153–160 (1985).Google Scholar
  34. Stein, P. J., Halliday, K. and Rasenick, M. M., J. Biol, Chem. 260:9081–9084 (1985).Google Scholar
  35. Stein, P. J., Rasenick, M. M. and Bitensky, M. W., Prog. Retinal Res. 1:222–238 (1982).CrossRefGoogle Scholar
  36. Sternweis, P. C., J. Biol. Chem. 261:631–637 (1986).Google Scholar
  37. Sternweis, P. C. and Robishaw, J. D., J. Biol. Chem. 259:13806–13813 (1984).Google Scholar
  38. Sulser, F. et al., Adv. Exp. Med. Biol. (this volume) (1987).Google Scholar
  39. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Brock, D., Cameron, S., Broach, J., Natsomoto, K. and Wigler, M., Cell 40:27–36 (1985).CrossRefGoogle Scholar
  40. Treisman, G., Bagley, S. and Gnegy, M., J. Neurochem. 41:1398–1406 (1983).CrossRefGoogle Scholar
  41. Von Hungen, K. and Roberts, S., Review of Neuroscience I 231-281 (1974).Google Scholar
  42. Yamamoto, T. and Shimizu, H., J. Neurochem. 40:629–636 (1983).CrossRefGoogle Scholar
  43. Zisapel, N., Levi, M. and Gozes, I. J., Neurochem. 34:26–32 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. M. Rasenick
    • 1
  • M. M. Marcus
    • 1
  • Y. Hatta
    • 1
  • F. DeLeon-Jones
    • 1
    • 2
  • S. Hatta
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Illinois College of MedicineChicagoUSA
  2. 2.Westside VA HospitalChicagoUSA

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