Role of the Maternal Carrier Proteins in the Supply of Thyroid Hormones to the Feto-Placental Unit: Evidence of a Feto-Placental Requirement for Thyroxine

  • Roger Ekins
  • Arun Sinha
  • Maria Ballabio
  • Mark Pickard
  • Michael Hubank
  • Zaidan al Mazidi
  • Mohamed Khaled
Part of the NATO ASI Series book series (NSSA, volume 161)


For a number of years, the consensus view amongst endocrinologists has been that thyroid hormones of maternal origin neither cross the placenta in significant amount1, nor are implicated in the development of the fetus in general, or of the fetal CNS in particular2. Nevertheless, for a number of reasons (some of which have been discussed in3), the validity of this view appeared to us to be open to doubt; we therefore initiated studies (ca 1980) specifically intended to verify or disprove some of the experimental evidence and theoretical postulates on which this view was based.


Thyroid Hormone Thyroxine Binding Globulin Free Hormone Hormone Transport Adult Progeny 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Roger Ekins
    • 1
  • Arun Sinha
    • 1
  • Maria Ballabio
    • 1
  • Mark Pickard
    • 1
  • Michael Hubank
    • 1
  • Zaidan al Mazidi
    • 1
  • Mohamed Khaled
    • 1
  1. 1.Department of Molecular EndocrinologyUniversity College and Middlesex School of Medicine University of LondonLondonUK

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