Thyroglobulin and Congenital Hypothyroidism
Thyroglobulin (Tg) is a glycoprotein which is released in minute amounts into the circulation by the thyroid gland. Under physiological conditions it can be measured in the serum of most individuals by modern RIA. The serum Tg concentration is elevated in various thyroid disorders (1). Since Tg is secreted by the thyroid gland only, its presence in the circulation should therefore indicate the presence of thyroid tissue. This report concerns the evaluation of Tg measurement in infants with congenital hypothyroidism (CH). Our results indicate that Tg RIA provides useful information about the presence or absence of functional thyroid tissue. It also allows easy evaluation of the function of remnant thyroid tissue in patients with CH who have been treated for several years.
KeywordsThyroid Gland Thyroid Tissue Congenital Hypothyroidism Serum Thyroglobulin Ectopic Thyroid
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- 4.B. Osotimehin, E. G. Black, R. HoffenbergGoogle Scholar
- Thyroglobulin concentration in neonatal blood: a possible test for neonatal hypothyroidism, Br Med J 2: 1467 (1978)Google Scholar
- 7.E. Roti, A. Gnudi, E. L. Braverman, G. Robuschi, R. Emanuele, P. Bandini, L. Benassi, A. Pagliani, and C. H. Emerson, Human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone. J Clin Endocrinol Metab 53: 813 (1981)PubMedCrossRefGoogle Scholar