Thyroglobulin and Congenital Hypothyroidism

  • Paul Czernichow
  • Juliane Leger
Part of the NATO ASI Series book series (NSSA, volume 161)


Thyroglobulin (Tg) is a glycoprotein which is released in minute amounts into the circulation by the thyroid gland. Under physiological conditions it can be measured in the serum of most individuals by modern RIA. The serum Tg concentration is elevated in various thyroid disorders (1). Since Tg is secreted by the thyroid gland only, its presence in the circulation should therefore indicate the presence of thyroid tissue. This report concerns the evaluation of Tg measurement in infants with congenital hypothyroidism (CH). Our results indicate that Tg RIA provides useful information about the presence or absence of functional thyroid tissue. It also allows easy evaluation of the function of remnant thyroid tissue in patients with CH who have been treated for several years.


Thyroid Gland Thyroid Tissue Congenital Hypothyroidism Serum Thyroglobulin Ectopic Thyroid 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Paul Czernichow
    • 1
  • Juliane Leger
    • 1
  1. 1.Hopital des Enfants-MaladesParisFrance

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