Thyroid Growth Blocking Antibodies and Congenital Hypothyroidism
In 1960 the simultaneous demonstration of thyroid autoantibodies in both mother and newborn sera in many cases of congenital hypothyroidism led to the hypothesis that maternal autoantibodies could pass through the placenta and induce fetal thyroid disease.1 In a recent study we demonstrated that 14% of normal pregnant women had positive titers for antimicrosomal antibodies with a positive correlation with the titer found in the newborn which had normal thyroid function. On the other hand only one newborn out of 104 with congenital hypothyroidism had positive titer.2 These results suggested that antimicrosomal antibodies did not play an important role in the pathogenesis of congenital hypothyroidism.
KeywordsCongenital Hypothyroidism Normal Pregnant Woman Transient Hypothyroidism Antimicrosomal Antibody Thyroid Growth
Unable to display preview. Download preview PDF.
- 5.H.A. Drexhage, G.F. Bottazzo and L. Bitensky et al, Thyroid growth-blocking antibodies in primary myxoedema, Nature 289: 594 (1981).Google Scholar
- 6.D. Doniach, Hashimoto’s thyroiditis and primary myxoedema viewed as separate entities, Eur. J. Clin. Invest. 11:245, (1981).Google Scholar
- 7.N. Matsuura, Y. Yamada and Y. NOhara et al, Familial neonatal transient hypohtyroidism due to maternal TSH-binding inhibitor immunoglobulins, N. Engl. J. Med. 303:738 (1980).Google Scholar
- 8.R.D. Van Der Gaag, H.A. Drexhage and J.H. Dussault, Role of maternal immunoglobulins blocking TSH-idnuced thyroid growth in sporadic forms of congenital hypothyroidism, Lancet 1: 246 (1985).Google Scholar
- 9.A.Svejgaard and L.P. Ryder, Disease associations, in: “Histocompatibility Techniques,” H.M. Dick and F. Kissemeyer-Neilson, eds, Elsevier/North Holland Biochemical Press, Amsterdam (1979).Google Scholar
- 10.F.S. Ambesi-Impiombato, L. Parks and H.G.Coons, Culture of hormone-dependent epithelial cells from rat thyroids, Proc. Natl. Acad. Sci. 77:3455 (1980).Google Scholar
- 11.S.J. Weiss, N.J. Philp and E.F. Grollman, Iodide transport in a continuous line of cultured cells from rat thyroid, Endocrinol. 114:1090 (1984).Google Scholar
- 12.J.H. Dussault and D.Bernier, 1251 Uptake by FRITL5 cells: a screening test of detect pregnant women at risk of giving birth to hypothyroid infants, Lancet 2: 1029 (1985).Google Scholar
- 13.M. Weiss and S.H. Ingbar, Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica, Science 219: 1331 (1983).Google Scholar
- 14.R.D. Van Der Gaag, A.M. Bloot and H.A. Drexhage, The thyroid and autoimmunity, in: “Proceeding of the International Symposium on Thyroid and Autoimmunity,” H.A. Drekhage and W.M. Wiersinga, eds, International Congress, Amsterdam (1986).Google Scholar