Thyroid Growth Blocking Antibodies and Congenital Hypothyroidism

  • Jean H. Dussault
Part of the NATO ASI Series book series (NSSA, volume 161)


In 1960 the simultaneous demonstration of thyroid autoantibodies in both mother and newborn sera in many cases of congenital hypothyroidism led to the hypothesis that maternal autoantibodies could pass through the placenta and induce fetal thyroid disease.1 In a recent study we demonstrated that 14% of normal pregnant women had positive titers for antimicrosomal antibodies with a positive correlation with the titer found in the newborn which had normal thyroid function. On the other hand only one newborn out of 104 with congenital hypothyroidism had positive titer.2 These results suggested that antimicrosomal antibodies did not play an important role in the pathogenesis of congenital hypothyroidism.


Congenital Hypothyroidism Normal Pregnant Woman Transient Hypothyroidism Antimicrosomal Antibody Thyroid Growth 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Jean H. Dussault
    • 1
  1. 1.Centre de Recherche du Réseau de Médecine Génétique du QuébecCHULSte-FoyCanada

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