Biochemical Changes in the Artery Wall during Genesis and Regression of Atheromatous Lesions

  • H. B. LoflandJr.
  • R. W. St. Clair
  • T. B. Clarkson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 26)


It is generally accepted that the formation of atheromatous lesions represents an interaction between plasma lipids (lipoproteins) and the arterial wall. In most species, including man, qualitative or quantitative changes in plasma lipids result in an accelerated rate of development of atherosclerosis. A growing body of evidence, however, also suggests that the arterial wall itself plays more than a passive role in this process.


Arterial Wall Atherosclerotic Lesion Cholesteryl Ester Squirrel Monkey Free Cholesterol 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • H. B. LoflandJr.
    • 1
  • R. W. St. Clair
    • 1
  • T. B. Clarkson
    • 1
  1. 1.Arteriosclerosis Research CenterBowman Gray School of MedicineWinston-SalemUSA

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