Hormonal Control of Lipolysis in Adipose Tissue

  • Daniel Steinberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 26)


It is now generally accepted that the mobilization of free fatty acids from adipose tissue stores is a key metabolic process. Stored triglycerides can only be mobilized as free fatty acids. Thus, mobilization of free fatty acids is a process as important as, or even more important than, mobilization of liver glycogen as glucose. The primary purpose of FFA mobilization is in the provision of caloric substrate to peripheral tissues but there are numerous additional metabolic consequences of FFA mobilization highly relevant to the context of this meeting. Some of these metabolic consequences for which good experimental evidence is available are the following:
  1. 1.

    Increased rate of fat deposition in the liver, which may under appropriate circumstances tend to produce fatty liver;

  2. 2.

    Increased rate of production of ketone bodies, which may be relevant to the genesis of ketosis under some circumstances;

  3. 3.

    Increased rate of production of very low density lipoproteins by the liver, which may be a factor in certain types of hyperlipoproteinemia;

  4. 4.

    Interference with the uptake and utilization of glucose by muscle, which may be a factor in the complex metabolic interrelationships in the diabetic state;

  5. 5.

    Effects on the coagulation system, tending to favor intravascular thrombosis.

Incompletely documented consequences include:
  1. 6.

    A tendency to increase overall body metabolism;

  2. 7.

    Effects on myocardial contractility;

  3. 8.

    An increase in number and firing rate of ectopic foci after myocardial infarction.



Adipose Tissue Adipose Tissue Store Monoglyceride Lipase Triglyceride Lipase Activity Lipase Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Huttunen, J.K., J. Ellingboe, R.C. Pittman, and D. Steinberg. Biochim. Biophys. Acta 218: 333 (1970).CrossRefGoogle Scholar
  2. 2.
    Huttunen, J.K., A.A. Aquino and, D. Steinberg. Biochim. Biophys. Acta 224: 295 (1970).PubMedCrossRefGoogle Scholar
  3. 3.
    Huttunen, J.K., D. Steinberg and, S. E. Mayer. Proc. Nat. Acad. Sci. 67: 290 (1970).PubMedCrossRefGoogle Scholar
  4. 4.
    Huttunen, J.K., D. Steinberg, and S.E. Mayer. Biochem. Biophys. Res. Comm. 41: 1350 (1970).PubMedCrossRefGoogle Scholar
  5. 5.
    Vaughan, M., J. Berger, and D. Steinberg. J. Biol. Chem. 239: 401 (1964).PubMedGoogle Scholar
  6. 6.
    Vaughan, M. and D. Steinberg, in Handbook of Physiology, Adipose Tissue. (Eds.) A.E. Renold and G.F. Cahill, Jr., American Physiological Society, Washington, D.S. (1965) p. 239.Google Scholar
  7. 7.
    Steinberg, D., in Advances in Cyclic Nucleotide Research, Proc. of Int. Conference on Physiol. and Pharmac. of Cyclic AMP, vol.l. (Eds.) P. Greengard, G.A. Robison and R. Paoletti, Raven Press, New York (1971) in press.Google Scholar
  8. 8.
    Walsh, D.A., J.P. Perkins and E.G. Krebs. J. Biol. Chem. 243: 3763 (1968).PubMedGoogle Scholar
  9. 9.
    Huttunen, J.K. and D. Steinberg. Biochim. Biophys. Acta 239: 410 (1971).Google Scholar
  10. 10.
    Rodbell, M., in Adipose Tissue, Regulation and Metabolic Functions. (Eds.) B. Jeaurenaud and D. Hepp, Academic cress, New York (1970).Google Scholar
  11. 11.
    Gill, G.N. and L.D. Garren. Biochem. Biophys. Res. Comm. 39: 335 (1970).PubMedCrossRefGoogle Scholar
  12. 12.
    Tao, M., M.L. Salas, and F. Lippman. Proc. Nat. Acad. Sci.(USA) 67: 408 (1970).CrossRefGoogle Scholar
  13. 13.
    Corbin, J.D. and E.G. Krebs. Biochem. Biophys. Res. Comm. 36: 328 (1969).PubMedCrossRefGoogle Scholar
  14. 14.
    Rizack, M.A. J. Biol. Chem. 236: 657 (1961).Google Scholar
  15. 15.
    Rizack, M.A. J. Biol. Chem. 239: 352 (1964).Google Scholar
  16. 16.
    Tsai, S.-C., P. Belfrage, and M. Vaughan. J. Lipid Res. 11: 466 (1970).PubMedGoogle Scholar
  17. 17.
    Corbin, J.D., E.M. Reimann, D.A. Walsh, and E.G. Krebs. J. Biol. Chem. 245: 4849 (1970).PubMedGoogle Scholar
  18. 18.
    Vaughan, M., D. Steinberg, F. Lieberman, and S. Stanley. Life Sci. 4: 1077 (1965).PubMedCrossRefGoogle Scholar
  19. 19.
    Manganiello, V.C., F. Murad, and M. Vaughan. J. Biol. Chem. 246: 2195 (1971).PubMedGoogle Scholar
  20. 20.
    Pittman, R.C., E. Golanty, and D. Steinberg. Biochim. Biophys. Acta, submitted for publication.Google Scholar
  21. 21.
    Strand, O., M. Vaughan, and D. Steinberg. J. Lipid Res. 5: 554 (1964).PubMedGoogle Scholar
  22. 22.
    Heller, R. and D. Steinberg. Fed. Proc. 30:1090 Abs, (1971).Google Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Daniel Steinberg
    • 1
  1. 1.Department of MedicineUniversity of California San DiegoLa JollaUSA

Personalised recommendations