Mechanisms of Hyperlipoproteinemia

  • Richard J. Havel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 26)


Our understanding of the pathogenesis of hyperlipoproteinemia stems from knowledge of the synthesis, secretion and metabolism of plasma lipoproteins and the regulation of These processes. Application of this knowledge in recent years has provided an explanation of several secondary hyperlipoproteinemias in terms of altered regulation of fat transport. This paper will review current knowledge of fat transport in lipoproteins and the increasing evidence that all major lipoprotein classes are involved in this process. The pathogenesis of certain secondary hyperlipoproteinemias will be discussed in the context of this review. Finally, a speculative assessment of the pathogenesis of the primary hyperlipoproteinemias will be attempted with particular reference to possible mechanisms of defective catabolism.


Free Fatty Acid Lipoprotein Lipase High Density Lipoprotein Mixed Hyperlipemia Glycogenosis Type 
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  1. 1.
    Havel, R.J. New Engl. J. Med. In press.Google Scholar
  2. 2.
    Werner, Bengt. Acta Chir. Scand. 132: 63 (1966)Google Scholar
  3. 3.
    Scherstén, T., S. Nilsson, E. Cahlin, M. Filipson and G. Brodin-Perssono Europ. J. Clin. Invest. I: 242 (1971)Google Scholar
  4. 4.
    Hamilton, R.L. This symposium.Google Scholar
  5. 5.
    Gotto, A.M., R.I. Levy, K. John, and D. S. Fredrickson. New Engl. J. Med. 284: 813 (1971)PubMedCrossRefGoogle Scholar
  6. 6.
    Glomset, J.A., K.R. Norum, and W. King. J. Clin. Invest. 49: 1827 (1970)PubMedCrossRefGoogle Scholar
  7. 7.
    Havel, R.J., V.G. Shore, B. Shore, and D. M. Bier. Circ. Res. 27: 595 (1970)PubMedCrossRefGoogle Scholar
  8. 8.
    LaRosa, J.C., R.I. Levy, P. Herbert, S.E. Lux, and D. S. Fredrickson. Biochem. Biophys. Res. Comm. 41: 57 (1970)PubMedCrossRefGoogle Scholar
  9. 9.
    Havel, R.J., M.L. Kashyap, and J. P. Kane. Circulation 42: 11–9 (1971)Google Scholar
  10. 10.
    Bilheimer, D., S. Eisenberg, and R. I. Levy. J. Clin. Invest. 50: 8a (1971)Google Scholar
  11. II.
    Shore, B. and V. Shore. Biochem. 8: 4510 (1969)CrossRefGoogle Scholar
  12. 12.
    Nestel, P.J., R. J. Havel and A. Bezmano J. Clin. Invest. 42: 1313 (1963).PubMedCrossRefGoogle Scholar
  13. 13.
    Redgrave, T.G. J. Clin. Invest. 49: 465 (1970)CrossRefGoogle Scholar
  14. 14.
    Bergman, E.N., R. J. Havel, B. M. Wolfe, and T. BfAhmer. J. Clin. Invest. 50: 1831 (1971)CrossRefGoogle Scholar
  15. 15.
    Sata, T. and R. J. Havel. Unpublished observations.Google Scholar
  16. 16.
    Gitlin, D., D.G. Cornwell, D. Nakasato, J.L. Oncley, W.L. Hughes, Jr., and C. A. Janeway. J. Clin. Invest. 37: 172 (1958)CrossRefGoogle Scholar
  17. 17.
    Havel, R.J. Atherosclerosis, Proc. II Internat. Symp. (Ed.) R.J. Jones, Springer Verlag, New York (1970) p. 210Google Scholar
  18. 18.
    Havel, R.J., J.P. Kane, E.O. Balasse, N. Segel, and L. V. Basso. J. Clin. Invest. 49: 2017 (1970)PubMedCrossRefGoogle Scholar
  19. 19.
    Basso, L.V. and R. J. Havel. J. Clin. Invest. 49: 537 (1970).PubMedCrossRefGoogle Scholar
  20. 20.
    Balasse, E.O., D. M. Bier, and R. J. Havel. Diabetologia 6: 618 (1970)Google Scholar
  21. 21.
    Havel, R.J., in Muscle Metabolism During Exercise. (Eds.) B. Pernow and B. Saltin, Plenum Press, New York (1971) p. 315.CrossRefGoogle Scholar
  22. 22.
    Havel, R.J. J. Clin. Invest. 36: 855 (1957)CrossRefGoogle Scholar
  23. 23.
    Wolfe, B.M., R.J. Havel, E.B. Marliss, J.P. Kane, and J. Seymour. J. Clin. Invest. 49: 104a (1970)CrossRefGoogle Scholar
  24. 24.
    Mayes, P.A. and J.M. Felts. Nature 215: 716 (1967)PubMedCrossRefGoogle Scholar
  25. 25.
    Barter, P.J. and P.J. Nestel. Metabolism. In press.Google Scholar
  26. 26.
    Sandhofer, F., K. Bolzano, S. Siler. and H. Braunsteiner. Klin. Wschr. 47: 1086 (1969)PubMedCrossRefGoogle Scholar
  27. 27.
    Havel, R.J., E.O. Balasse, H.E. Williams, J.P. Kane, and N. Segel. Trans. Assoc. Amer. Physicians 82: 305 (1969)Google Scholar
  28. 28.
    Farber, E. Adv. Lipid Res. 5: 119 (1967)PubMedGoogle Scholar
  29. 29.
    Havel, R.J. Calif. Med. 115: 23 (1971)PubMedGoogle Scholar
  30. 30.
    Marsh, J.B. and D.L. Draekin. Metabolism 9: 946 (1960)PubMedGoogle Scholar
  31. 31.
    Baxter, J.H., H.C. Goodman, and R.J. Havel. J. Clin. Invest. 39: 455 (1960)PubMedCrossRefGoogle Scholar
  32. 32.
    Bagdade, J.D., D. Porte, Jr., and E. L. Bierman. New Engl. J. Med. 276: 427 (1967)PubMedCrossRefGoogle Scholar
  33. 33.
    Havel, R.J. Adv. Int. Med. 15: 117 (1969)Google Scholar
  34. 34.
    Porte, D., Jr., D.D. O’Hara, and R.H. Williams. Metabolism 15: 107 (1966)PubMedCrossRefGoogle Scholar
  35. 35.
    Glueck, C.J., A.P. Kaplan, R.I. Levy, H. Greten, H. Gralnick, and D.S. Fredrickson. Ann. Int. Med. 71: 1051 (1969).PubMedCrossRefGoogle Scholar
  36. 36.
    Fielding, C.J. Personal communicationGoogle Scholar
  37. 37.
    Whayne, T.F. and J.M. Felts. Circulation 62: 111–6 (1970)Google Scholar
  38. 38.
    Shafrir, E. J. Clin. Invest. 37: 1775 (1958)CrossRefGoogle Scholar
  39. 39.
    Morell, A.G., G. Gregoriadis, I.H. Scheinberg, J. Hickman and G. Ashwell. J. Biol. Chem. 246: 1461 (1971)PubMedGoogle Scholar
  40. 40.
    Margolis, S. and R.G. Langdon, J. Biol. Chem. 241: 469 (1966)PubMedGoogle Scholar
  41. 41.
    Fredrickson, D.S., R.I. Levy, and R.S. Lees. New Engl. J. Med. 276: 32 (1967)Google Scholar
  42. 42.
    Fredrickson, D., K. Ono, and L.L. Davis. J. Lipid Res. 4: 24 (1963)PubMedGoogle Scholar
  43. 43.
    Sandhofer, F., S. Sailer, M. Herbst, and H. Braunsteiner. Dtsch. Med. Wschr. 90: 755 (1965)PubMedCrossRefGoogle Scholar
  44. 44.
    Boberg, J. Acta Univ. Upsaliensis. 105: 1 (1971)Google Scholar
  45. 45.
    Persson, B., P. Bjbrntorp, and B. Hood. Metabolism 15: 730 (1966).PubMedCrossRefGoogle Scholar
  46. 46.
    Reaven, G.M., R.L. Lerner, M. P. Stern, and J.W. Farquhar. J. Clin. Invest. 46: 1756 (1967)PubMedCrossRefGoogle Scholar
  47. 47.
    Quarfordt, S., R.I. Levy, and D.S. Fredrickson. J. Clin. Invest. 50: 75 (1971)CrossRefGoogle Scholar
  48. 48.
    Hazzard, W.R. and E. L. Bierman. Clin. Res. 19: 476 (1971)Google Scholar
  49. 49.
    Langer, T., W. Strober and R.I. Levy. J. Clin. Invest. 48: 49a (1969)Google Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Richard J. Havel
    • 1
  1. 1.Cardiovascular Research Institute and Department of MedicineUniversity of California School of MedicineSan FranciscoUSA

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