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The Apolipoproteins

  • Donald S. Fredrickson
  • Samuel E. Lux
  • Peter N. Herbert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 26)

Abstract

As the circulatory system evolved in higher organisms, one of the problems that had to be overcome was the transport of fats and other apolar substances having low affinity for water. At least in mammals, binding to albumin became the vehicle for carrying out the exceedingly rapid movement of unesterified fatty acids that exist in extracellular fluid as anions (FFA). Different proteins were selected to transport the esterified fatty acids and sterols that make up the bulk of lipids in plasma, as well as acyclic alcohols and traces of hydrocarbons. These proteins combined with the lipids to form macromolecular complexes which today we call lipoproteins.

Keywords

Sialic Acid High Density Lipoprotein DEAE Cellulose Polymorphic Form Isoelectric Focussing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Donald S. Fredrickson
    • 1
  • Samuel E. Lux
    • 1
  • Peter N. Herbert
    • 1
  1. 1.Molecular Disease BranchNational Heart and Lung InstituteBethesdaUSA

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