Abstracts of Submitted Papers
The mechanism of alcoholic hyperlipemia was studied in rats fed liquid diets with 36% of calories as ethanol or carbohydrate (controls). 3H was given intragastrically and 14C-lysine injected intravenously with or without Triton. Ethanol increased serum lipid concentration several fold, mainly in the very low density lipoprotein fraction (VLDL) with enhanced specific activities of both lipid and protein moieties. VLDL labeling was also increased n alcohol fed rats after injectingLlabeled chylomicrons (14C-palmitate, 3H-glycerol), and the 14C/3H ratio tripled, incriminating increased production of serum lipids rather than decreased removal of dietary chylomicrons. Furthermore, blocking serum lipid removal with Triton did not prevent the lipemic effect of ethanol. To investigate the source of increased serum lipids, intestinal lymph was diverteçi Ethanol still increased significantly the incorporation of 14C-lysine into serum lipoproteins, but not into chylous lipoproteins, indicating a non-intestinal (probably hepatic) site of increased lipoprotein production. However, ethanol also increased lymph lipid output and incorporation of dietary 3H-palmitate into lymph lipids. This may be explained by the findings that ethanol in vitro, or previous ethanol feeding in vivo, inhibited 14C-palmitate oxidation by intestinal slices. Thus alcoholic hyperlipemia may result from both enhanced hepatic lipoprotein production and decreased intestinal fat oxidation.
KeywordsBile Acid Nicotinic Acid Serum Cholesterol Plasma Cholesterol High Density Lipoprotein
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