Effects of Drugs on the Metabolism of Bile Acids

  • N. B. Myant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 26)


Bile acids are the main end products of the breakdown of cholesterol and their metabolism is intimately linked with that of cholesterol. Hence, the study of the effects of drugs on bile acid metabolism, apart from its intrinsic interest, is relevant to the problem of hypercholesterolaemia. Drugs that modify bile acid metabolism may also be used to produce experimental situations that provide information as to how sterol. metabolism is regulated. In this review I shall describe briefly those steps in the synthesis and subsequent fate of bile acids that are likely to be susceptible to the actions of drugs and I shall then discuss the effects of various agents, including hormones and certain dietary factors, that are known to influence bile acid metabolism.


Bile Acid Bile Salt Cholic Acid Faecal Excretion Total Bile Acid 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • N. B. Myant
    • 1
  1. 1.Medical Research Council Lipid Metabolism UnitHammersmith HospitalLondonUK

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