Skip to main content
SpringerLink
Log in
Book cover

Principles of Paediatric Pharmacology pp 101–150Cite as

The Central Nervous System

  • Chapter

  • 85 Accesses

Abstract

The intracranial structures comprise the hindbrain which includes the medulla oblongata, the pons, and the cerebellum; central to this is the midbrain whose principal structures are corpora quadrigemina, or the superior and inferior colliculi. The former are concerned with central visual, and pupillary reflexes, and the latter with auditory reflexes. The red nuclei and the substantia nigra, each being part of the extrapyramidal system, are located in the midbrain. The cerebellar peduncles, which are massive interconnecting bundles of neurones are also in the midbrain.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggestions for Further Reading

Anatomy and Organisation

  • Bonati, M., Kanto, J. and Tognoni, G. (1982) ‘Clinical Pharmacokinetics of Spinal Fluid’, Clin. Pharmacokinet., 7, 312 - 335

    Article  Google Scholar 

  • Johnston, M.V. and Singer, H.S. (1982) ‘Brain Neurotransmitters and Neuro-modulators in Pediatrics’, Pediatrics, 70, 57 - 68

    Google Scholar 

  • Nauta, W.J.H. and Fiertag, M. (1979) ‘The Organization of the Brain’, Scientific American, 241 (3), 78 - 105

    Article  Google Scholar 

  • Nathanson, J.A. (1977) ‘Cyclic Nucleotides and Nervous System Function’, Physiol. Rev., 57, 157 - 256

    Google Scholar 

  • Stevens, C.F. (1979) ‘The Neuron’, Scientific American, 241 (3), 49 - 70

    Article  Google Scholar 

Psychotrophic Drugs

  • DeLong, R. (1978) ‘Lithium Carbonate Treatment of Select Behaviour Disorders in Children Suggesting Manic-depressive Disorders’, J. Pediat., 93, 689 - 694

    Article  Google Scholar 

  • Frommer, E.A. (1967) ‘Treatment of Childhood Depression with Anti-depressant Drugs’, Br. Med. J., i, 729 - 732

    Article  Google Scholar 

  • Jorgenson, O.S., Lober, M., Christiansen, J. and Gram, L.F. (1980) ‘Plasma Concentration and Clinical Effect in Imipramine Treatment of Childhood Enuresis’, Clin. Pharmacokinet., 5, 386 - 393

    Article  Google Scholar 

  • McIntyre, I.M., Norman, T.R., Burrows, G.D. and Maguire, K.P. (1982) ‘Pharmacokinetics of Nomifensine after a Single Dose’, Br. J. Pharmacol., 13, 740 - 743

    Google Scholar 

  • Robinson, D.S., Nies, A., Ravaris, C.L., Ives, J.O. and Bartlett, D. (1978) ‘Clinical Psychopharmacology of Phenelzine: MAO Activity and Clinical Response’, in Psychopharmacology, a Generation of Progress (eds Lipton, M.A., de Mascio, A. and Killam, K.F., Raven Press, New York ), pp. 961 - 973

    Google Scholar 

  • Rosenbaum, J.F. (1982) ‘The Drug Treatment of Anxiety’, New Engl. J. Med., 306, 401 - 404

    Article  Google Scholar 

Sedatives and Hypnotics

  • Breimer, D.D. (1979) ‘Clinical Pharmacology of Hypnotics’, Clin. Pharmacokinet., 2, 93 - 96

    Article  Google Scholar 

  • Gillin, J.C., Mendelson, W.B., Sitaram, N. and Wyatt, R.J. (1978) ‘Neuropharmacology of Sleep and Wakefulness’, Ann. Rev. Pharmacol. Toxicol., 18, 563 - 579

    Article  Google Scholar 

Analgesics

  • Ahlstrom, B.D., Bohne, P., Noack, G. and Paalzow, L. (1979) ‘Morphine Kinetics in Children’, Clin. Pharmacol. Ther., 26, 354 - 365

    Google Scholar 

  • Beaver, W.T. (1966) ‘Mild Analgesics. — a Review of Their Clinical Pharmacology’, Am. J. med. Set, 250, 577 - 604

    Google Scholar 

  • Done, A.K., Yaffe, S.J. and Clayton, J.M. (1979) ‘Aspirin Dosage for Infants and Children’, J. Pediat., 95, 617 - 625

    Article  Google Scholar 

  • Levy, G. (1978) ‘Clinical Pharmacokinetics of Aspirin’, Pediatrics, 62, 867 - 872

    Google Scholar 

  • Mather, L.E. and Meffin, P.J. (1978) ‘Clinical Pharmacokinetics: Pethidine’, Clin. Pharmacokinet., 3, 352 - 368

    Article  Google Scholar 

  • Murphree, H.B. (1962) ‘Clinical Pharmacology of Potent Analgesics’, Clin. Pharmacol. Ther., 3, 473 - 504

    Google Scholar 

  • Peterson, R.G. and Rumack, B.H. (1978) ‘Pharmacokinetics of Acetaminophen in Children’, Pediatrics, 62, 877 - 879

    Google Scholar 

  • Simon, E.J. and Hiller, J.M. (1978) ‘The Opiate Receptors’, Ann. Rev. Pharmacol. Toxicol., 18, 371 - 393

    Article  Google Scholar 

The Anticonvulsants

  • Brown, J.K. (1973) ‘Convulsions in the Newborn Period’, Devel. Med. Child Neurol., 15, 823 - 846

    Article  Google Scholar 

  • Jeavons, P.M., Clark, J.E. and Maheshwarlk, M.C. (1977) ‘Treatment of Generalized Epilepsies of Childhood and Adolescence with Sodium Valproate (Epilim)’, Devel. Med. Child Neurol., 19, 8 - 25

    Google Scholar 

  • Livingston, S. (1972) Comprehensive Management of Epilepsy in Infancy, Childhood and Adolescence (Charles C. Thomas, Springfield, Illinois )

    Google Scholar 

Anaesthesia

  • Clements, J.A., Nimmo, W.S. and Grant, I.S. (1982) ‘Bioavailability, Pharmacokinetics and Analgesic Activity of Ketamine in Humans’, J. pharm. Sci., 71, 539 - 541

    Article  Google Scholar 

  • Fiserova-Bergerova, A. and Holaday, D.A. (1979) ‘Uptake and Clearance of Inhalation Anaesthetics in Man’, Drug Metab. Rev., 9, 43 - 60

    Article  Google Scholar 

  • Ghoneim, M.M. and Korttila, K. (1977) ‘Pharmacokinetics of Intravenous Anaesthetics: Duplications for Clinical Use’, Clin. Pharmacokinet., 2, 344 - 372

    Article  Google Scholar 

  • Koblin, D.D. and Eger, E.I. (1979) ‘Theories of Narcosis’, New Engl. J. Med., 301, 1222 - 1224

    Article  Google Scholar 

  • Mihaly, G.W., Moore, R.G., Thomas, J., Triggs, E.J., Thomas, D. and Shanks, C.A. (1978) ‘The Pharmacokinetics and Metabolism of the Anilide Local Anaesthetics in Neonates: I. Lignocaine’, Eur. J. Clin. Pharmacol., 13, 143 - 152

    Article  Google Scholar 

  • Ngai, S.H. (1980) ‘Effects of Anesthetics on Various Organs’, New Engl. J. Med., 130, 564 - 566

    Article  Google Scholar 

  • Roth, S.H. (1979) ‘Physical Mechanisms of Anaesthesia’, Ann. Rev. Pharmacol. Toxicol., 19, 159-178

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Adelaide, Australia

    George M. Maxwell (Professor of Paediatrics)

Authors
  1. George M. Maxwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1984 George M. Maxwell

About this chapter

Cite this chapter

Maxwell, G.M. (1984). The Central Nervous System. In: Principles of Paediatric Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7544-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7544-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7546-3

  • Online ISBN: 978-1-4684-7544-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation